{"title":"荷叶核植物抑制伯氏疟原虫增殖对小鼠胰岛β细胞功能和贫血指标的影响。","authors":"I Onyesom, U E Uzuegbu, F O Adu, G E Ayeta","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Malaria remains one of the major causes of childhood mortality in many parts of the world, especially in the sub-Saharan Africa, including Nigeria. Increasing chemotherapeutic failure and side effects of available antimalarial drugs have promoted the use of natural herbs for the treatment of malaria in Nigerian communities.</p><p><strong>Objective: </strong>To study the phytosuppression of P berghei by Nauclea latifolia and its effects on the indices of anaemia and pancreatic beta cell function in experimental mice.</p><p><strong>Methods: </strong>Fifty mice were divided into 10 groups (n=5) and used for the study. Group 1 (control) were uninfected but given placebo. Group 2 were infected with P berghei and treated with placebo. Groups 3, 4, 5, 8, 9 and 10 received N. latifolia treatment, while Groups 6 and 7 received standard chloroquine treatment. Groups 3, 4, 5 and 6 were however infected with the malarial parasite. Blood samples were collected by heart puncture and prepared for the estimation of haemoglobin, insulin and glucose. The pancreatic beta cell function (HOMA-beta) was determined using the fasting serum insulin and glucose levels as documented.</p><p><strong>Results: </strong>P. berghei malaria infection caused a significant reduction in haemoglobin that led to anaemia in the mice, There were elevated HOMA-beta) in the parasitized and chloroquine treated groups, suggesting possible pancreatic beta cell dysfunction. Treatment with N. latifolia showed parasitaemia suppression and' improved pancreatic beta cell function and haemoglobin concentrations.</p><p><strong>Conclusion: </strong>N. latifolia contains bioactive phytochemicals that suppresses malaria parasite multiplication and improves pancreatic beta cell function.</p>","PeriodicalId":19202,"journal":{"name":"Nigerian quarterly journal of hospital medicine","volume":"25 3","pages":"142-4"},"PeriodicalIF":0.0000,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phyto suppression of Plasmodium berghei Multiplication by Nauclea latifolia improves the Indices of Pancreatic Beta Cell Function and Anaemia in Experimental Mice.\",\"authors\":\"I Onyesom, U E Uzuegbu, F O Adu, G E Ayeta\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Malaria remains one of the major causes of childhood mortality in many parts of the world, especially in the sub-Saharan Africa, including Nigeria. Increasing chemotherapeutic failure and side effects of available antimalarial drugs have promoted the use of natural herbs for the treatment of malaria in Nigerian communities.</p><p><strong>Objective: </strong>To study the phytosuppression of P berghei by Nauclea latifolia and its effects on the indices of anaemia and pancreatic beta cell function in experimental mice.</p><p><strong>Methods: </strong>Fifty mice were divided into 10 groups (n=5) and used for the study. Group 1 (control) were uninfected but given placebo. Group 2 were infected with P berghei and treated with placebo. Groups 3, 4, 5, 8, 9 and 10 received N. latifolia treatment, while Groups 6 and 7 received standard chloroquine treatment. Groups 3, 4, 5 and 6 were however infected with the malarial parasite. Blood samples were collected by heart puncture and prepared for the estimation of haemoglobin, insulin and glucose. The pancreatic beta cell function (HOMA-beta) was determined using the fasting serum insulin and glucose levels as documented.</p><p><strong>Results: </strong>P. berghei malaria infection caused a significant reduction in haemoglobin that led to anaemia in the mice, There were elevated HOMA-beta) in the parasitized and chloroquine treated groups, suggesting possible pancreatic beta cell dysfunction. Treatment with N. latifolia showed parasitaemia suppression and' improved pancreatic beta cell function and haemoglobin concentrations.</p><p><strong>Conclusion: </strong>N. latifolia contains bioactive phytochemicals that suppresses malaria parasite multiplication and improves pancreatic beta cell function.</p>\",\"PeriodicalId\":19202,\"journal\":{\"name\":\"Nigerian quarterly journal of hospital medicine\",\"volume\":\"25 3\",\"pages\":\"142-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian quarterly journal of hospital medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian quarterly journal of hospital medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Phyto suppression of Plasmodium berghei Multiplication by Nauclea latifolia improves the Indices of Pancreatic Beta Cell Function and Anaemia in Experimental Mice.
Background: Malaria remains one of the major causes of childhood mortality in many parts of the world, especially in the sub-Saharan Africa, including Nigeria. Increasing chemotherapeutic failure and side effects of available antimalarial drugs have promoted the use of natural herbs for the treatment of malaria in Nigerian communities.
Objective: To study the phytosuppression of P berghei by Nauclea latifolia and its effects on the indices of anaemia and pancreatic beta cell function in experimental mice.
Methods: Fifty mice were divided into 10 groups (n=5) and used for the study. Group 1 (control) were uninfected but given placebo. Group 2 were infected with P berghei and treated with placebo. Groups 3, 4, 5, 8, 9 and 10 received N. latifolia treatment, while Groups 6 and 7 received standard chloroquine treatment. Groups 3, 4, 5 and 6 were however infected with the malarial parasite. Blood samples were collected by heart puncture and prepared for the estimation of haemoglobin, insulin and glucose. The pancreatic beta cell function (HOMA-beta) was determined using the fasting serum insulin and glucose levels as documented.
Results: P. berghei malaria infection caused a significant reduction in haemoglobin that led to anaemia in the mice, There were elevated HOMA-beta) in the parasitized and chloroquine treated groups, suggesting possible pancreatic beta cell dysfunction. Treatment with N. latifolia showed parasitaemia suppression and' improved pancreatic beta cell function and haemoglobin concentrations.
Conclusion: N. latifolia contains bioactive phytochemicals that suppresses malaria parasite multiplication and improves pancreatic beta cell function.