S M Yusuf, U A Tiijani, Maiyaki M B, I Nashabaru, A E Uloko, I D Gezaqa
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引用次数: 0
摘要
背景:扁平苔藓是一种慢性炎症性疾病。最近,有研究表明LP与大量患者的血脂异常有关,而不受其他原因的影响。目的:本研究的目的是调查脂肪肝患者血脂异常的患病率和相关危险因素。方法:本研究纳入病例对照研究180例。研究对象为90名扁平苔藓患者(男性39名,女性51名)和90名对照组(男性44名,女性46名),分别从尼日利亚卡诺市Amnihu Kano教学医院皮肤科门诊连续招募。结果:LP患者血脂异常患病率(32%)高于对照组(24%),p=0.208。我们的研究显示,男性LP患者发生血脂异常的倾向更高(OR 5.66, CI 1.73-19.59)。同样,疾病持续2个月是发生血脂异常的一个强有力的预测因子(OR 5.65, CI 1.12-38.3)。在两个研究组之间,血糖水平、体重指数或血压没有显著差异。结论:在本研究中,LP患者中血脂异常的患病率较高,男性和病程延长是强有力的预测因素。我们需要更大规模的进一步研究来确定LP患者的患病率和血脂异常的独立预测因素。
Dyslipidemia: Prevalence and associated risk factors among patients with Lichen Planus in Kano, North-West Nigeria.
Background: Lichen planus (LP) is a chronic inflammatory disorder. Recently, there are suggestions that LP is associated with dyslipidemia in a large series of patients independent of other causes.
Objective: The objective of this study was to investigate the prevalence and associated risk factors for dyslipidaemia among patients with LP.
Methods: This case-control study included 180.subjects, 90 with lichen planus (39 men and 51 Women) and 90 (44 men and 46 women) controls consecutively recruited from the outpatient Dermatology clinic of Amnihu Kano Teaching Hospital Kano-Nigeria.
Results: The prevalence of dyslipidemia was found to be higher among LP patients (32%) than the corol group (24%), p=0.208. Our study showed that male patients with LP have higher tendencies to develop dyslipidemia (OR 5.66, CI 1.73-19.59). Equally the duration of illness t 2 months was found to be a strong predictor of developing dyslipidemia (OR 5.65, CI 1.12-38.3). No significant differences were observed in glucose levels, body mass index, or blood pressure between the two study groups.
Conclusion: The prevalence of dyslipidaemia among patients with LP in this study was high with male gender and increased-duration of illness being strong predictors. There is need for further studies on a larger scale to establish the prevalence and independent predictors of dyslipidaemia in patients with LP in our setting.