癌症中的连接蛋白和泛连接蛋白通道。

Q1 Biochemistry, Genetics and Molecular Biology BMC Cell Biology Pub Date : 2016-05-24 DOI:10.1186/s12860-016-0094-8
Jean X Jiang, Silvia Penuela
{"title":"癌症中的连接蛋白和泛连接蛋白通道。","authors":"Jean X Jiang,&nbsp;Silvia Penuela","doi":"10.1186/s12860-016-0094-8","DOIUrl":null,"url":null,"abstract":"<p><p>Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and their effect in cellular communication, can either enhance or suppress tumorigenesis and metastasis. In this review, we will highlight the latest reports on the role of the well characterized connexin family and its ability to form gap junctions and hemichannels in cancer. We will also introduce the more recently discovered family of pannexin channels and our current knowledge about their involvement in cancer progression. </p>","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 Suppl 1 ","pages":"12"},"PeriodicalIF":0.0000,"publicationDate":"2016-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0094-8","citationCount":"1","resultStr":"{\"title\":\"Connexin and pannexin channels in cancer.\",\"authors\":\"Jean X Jiang,&nbsp;Silvia Penuela\",\"doi\":\"10.1186/s12860-016-0094-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and their effect in cellular communication, can either enhance or suppress tumorigenesis and metastasis. In this review, we will highlight the latest reports on the role of the well characterized connexin family and its ability to form gap junctions and hemichannels in cancer. We will also introduce the more recently discovered family of pannexin channels and our current knowledge about their involvement in cancer progression. </p>\",\"PeriodicalId\":9051,\"journal\":{\"name\":\"BMC Cell Biology\",\"volume\":\"17 Suppl 1 \",\"pages\":\"12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s12860-016-0094-8\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s12860-016-0094-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12860-016-0094-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 1

摘要

细胞间通过连接蛋白间隙连接直接接触,或细胞与细胞外环境之间通过连接蛋白通道或连接蛋白半通道进行通信,是细胞功能和组织稳态的关键因素。在不同癌症类型的恶性转化过程中,这些连接蛋白和泛连接蛋白通道的失调及其在细胞通讯中的作用可以增强或抑制肿瘤的发生和转移。在这篇综述中,我们将重点介绍最近报道的连接蛋白家族的作用及其在癌症中形成间隙连接和半通道的能力。我们还将介绍最近发现的pannexin通道家族以及我们目前对它们参与癌症进展的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Connexin and pannexin channels in cancer.

Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and their effect in cellular communication, can either enhance or suppress tumorigenesis and metastasis. In this review, we will highlight the latest reports on the role of the well characterized connexin family and its ability to form gap junctions and hemichannels in cancer. We will also introduce the more recently discovered family of pannexin channels and our current knowledge about their involvement in cancer progression.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
BMC Cell Biology
BMC Cell Biology 生物-细胞生物学
CiteScore
7.30
自引率
0.00%
发文量
0
审稿时长
12 months
期刊介绍: BMC Molecular and Cell Biology, formerly known as BMC Cell Biology, is an open access journal that considers articles on all aspects of both eukaryotic and prokaryotic cell and molecular biology, including structural and functional cell biology, DNA and RNA in a cellular context and biochemistry, as well as research using both the experimental and theoretical aspects of physics to study biological processes and investigations into the structure of biological macromolecules.
期刊最新文献
Mitotic activity patterns and cytoskeletal changes throughout the progression of diapause developmental program in Daphnia. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways. Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. Comparative evaluation of mesenchymal stromal cells from umbilical cord and amniotic membrane in xeno-free conditions. The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1