全氟烷基物质与高血压的关系:系统综述和荟萃分析

IF 7.7 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Research Pub Date : 2023-09-01 DOI:10.1016/j.envres.2023.116362
Kai Pan , Jie Xu , Xianping Long , Lilin Yang , Zhiyu Huang , Jie Yu
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引用次数: 0

摘要

高血压是心血管疾病(cvd)的重要危险因素,也是过早死亡的主要原因。流行病学研究发现,全氟烷基物质(PFASs)与高血压有关。然而,PFASs与高血压之间的相关性尚未有系统的报道。基于人口流行病学调查的证据,我们根据系统评价和荟萃分析(PRISMA)指南的首选报告项目进行了荟萃分析,以评估PFASs暴露与高血压之间的相关性。本研究检索PubMed、Web of science、Embase 3个数据库,共纳入13篇文献,共81,096名受试者。采用I2统计量评价文献异质性,随机效应模型(I2 >50%)和固定效应模型(I2 <50%)用于合并meta分析的研究。结果显示,PFNA (OR = 1.11, 95% CI: 1.04 ~ 1.19)、PFOA (OR = 1.12, 95% CI: 1.02 ~ 1.23)、PFOS (OR = 1.19, 95% CI: 1.06 ~ 1.34)、PFHxS (OR = 1.03, 95% CI: 1.00 ~ 1.06)与高血压有显著相关性,其他PFASs(∑PFAS、PFDA、PFUnDA)与高血压无统计学意义。此外,PFNA (OR = 1.12, 95% CI: 1.03-1.22)、PFOA (OR = 1.12, 95% CI: 1.01-1.25)和PFOS (OR = 1.12, 95% CI: 1.00-1.25)暴露与男性高血压风险呈正相关,但与女性无关。我们的研究表明,PFASs是高血压的危险因素,在PFASs暴露人群中存在显著的性别差异。具体来说,与女性相比,暴露于PFNA、PFOA和PFOS的男性患高血压的风险更高。然而,PFASs促进高血压发展的确切机制还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The relationship between perfluoroalkyl substances and hypertension: A systematic review and meta-analysis

Hypertension is an important risk factor for cardiovascular diseases (CVDs) and a leading cause of premature death. Epidemiological studies have found that perfluoroalkyl substances (PFASs) are associated with hypertension. However, the correlation between PFASs and hypertension has not been systematically reported. Based on evidence from population epidemiological surveys, we conducted a meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to assess the correlation between PFASs exposure and hypertension. In this study, three databases of PubMed, Web of science, Embase were searched and 13 literatures with 81,096 participants were included. Literature heterogeneity was evaluated by I2 statistic, and the random effect model (I2 > 50%) and fixed effect model (I2 < 50%) were used to combine the studies in meta-analysis. The results showed that PFNA (OR = 1.11, 95% CI: 1.04–1.19), PFOA (OR = 1.12, 95% CI: 1.02–1.23), PFOS (OR = 1.19, 95% CI: 1.06–1.34) and PFHxS (OR = 1.03, 95% CI: 1.00–1.06) were significantly associated with hypertension, while other types of PFASs (∑PFAS, PFDA, PFUnDA) had no statistical significance. In addition, PFNA (OR = 1.12, 95% CI: 1.03–1.22), PFOA (OR = 1.12, 95% CI: 1.01–1.25) and PFOS (OR = 1.12, 95% CI: 1.00–1.25) exposure were positively correlated with the risk of hypertension in men, but not in women. Our study reveals that PFASs are risk factors for hypertension, with notable gender differences observed in PFASs-exposed populations. Specifically, males exposed to PFNA, PFOA, and PFOS exhibit a higher risk of hypertension compared to females. However, further investigations are needed to delve into the precise mechanism through which PFASs contribute to the development of hypertension.

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来源期刊
Environmental Research
Environmental Research 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
12.60
自引率
8.40%
发文量
2480
审稿时长
4.7 months
期刊介绍: The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.
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