鲁昂大学用于神经保护目的的硫酸镁的使用情况

Gynecologie Obstetrique & Fertilite Pub Date : 2016-07-01 DOI:10.1016/j.gyobfe.2016.05.008

J.-C. Millochau , S. Marret , S. Oden , E. Verspyck

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引用次数: 1

摘要

目的虽然硫酸镁对预防极早产儿产前脑瘫的益处已被证实，但仍存在不愿使用硫酸镁的情况。本研究的目的是对我们在鲁昂大学医院使用硫酸镁预防脑瘫的做法进行评估，以报告其可行性和安全性，以便推广使用。方法2014年1 - 6月在鲁昂大学医院进行的单中心回顾性研究。所有在33周之前分娩或在33周之前被认为有即将分娩风险的患者被纳入(n = 86)。结果在33周前分娩的患者中(n = 82)， 91.5%的患者给予硫酸镁负荷剂量。治疗主要由助产士进行(98.6%)，通常在产房进行(82.4%)，平均给药时间为8.9±17.5小时。如果患者出现呼吸缓慢并伴有意识受损，则必须停止治疗。结论本研究表明，硫酸镁在临床应用中易于使用。

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État des lieux de l’utilisation du sulfate de magnésium à visée neuroprotectrice au CHU de Rouen

Objectives

Although the benefit of magnesium sulfate to prevent cerebral palsy in antenatal on very preterm infants has been shown, there is still reluctance to use it. The aim of this study was to conduct an assessment of our practice using magnesium sulfate to prevent cerebral palsy at Rouen University Hospital to report its feasibility and safety in order to spread its use.

Methods

Unicentric and retrospective study, at the University Hospital of Rouen, between January and June 2014. All patients who delivered before 33 weeks or considered at risk of imminent delivery before 33 weeks were included (n = 86).

Results

Among the patients who delivered before 33 weeks (n = 82), a magnesium sulfate loading dose was administrated in 91.5% of cases. Treatment was mainly established and monitored by midwives (98.6%), usually in the delivery room (82.4%), and with an average duration of administration of 8.9 ± 17.5 hours. The treatment had to be stopped in a patient who presented bradypnea associated with impaired consciousness.