肝硬化性心肌病:心功能损害的阶段与肝病的严重程度是否相关?

IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Libyan Journal of Medicine Pub Date : 2017-12-01 DOI:10.1080/19932820.2017.1283162
Rania Hammami, Mouna Boudabbous, Jihen Jdidi, Fatma Trabelsi, Fakher Mroua, Rahma Kallel, Ali Amouri, Dorra Abid, Nabil Tahri, Leila Abid, Samir Kammoun
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引用次数: 0

摘要

肝硬化心肌病与预后不良和肝移植或介入手术后急性心力衰竭的风险有关。我们的目的是评估心脏功能损害的严重程度与肝病之间的关系。八十名患者和八十名对照组接受了超声心动图、组织多普勒成像和斑点追踪测量。我们评估了超声心动图参数与 Child 和 MELD 评分之间的相关性。与对照组相比,肝硬化患者的收缩参数功能(s 波,p < 0.001)和整体纵向应变(p < 0.001)以及舒张参数明显受损。不同组别在收缩功能和舒张功能方面的 "Child评分 "没有差异。矛盾的是,左心房大小与Child评分(p = 0.01,r = 0.26)和MELD评分(p = 0.02,r = 0.24)呈正相关。与代偿期患者相比,失代偿期患者的左心室射血分数明显较低(p = 0.02)。我们没有发现肝病严重程度与心功能不全之间有任何关联。因此,无论肝病严重程度如何,所有肝硬化患者在进行介入和外科手术前都应进行经胸超声心动图检查。
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Cirrhotic cardiomyopathy: is there any correlation between the stage of cardiac impairment and the severity of liver disease?

Cirrhotic cardiomyopathy is associated with poor prognosis and risk of acute heart failure after liver transplantation or interventional procedures. We aimed to assess the relationship between the severity of cardiac impairment and hepatic disease. Eighty patients and eighty controls underwent echocardiography, tissue Doppler imaging and speckle tracking measures. We assess the correlation between echocardiographic parameters and Child and MELD scores. Systolic parameters function (s wave, p < 0.001) and global longitudinal strain (p < 0.001) as well as diastolic parameters were significantly more impaired in cirrhotic patients compared to controls. There were no differences among the different groups in 'Child score' regarding systolic function as well as diastolic function. Paradoxically, the left atrium size correlated positively to both Child (p = 0.01, r = 0.26) and MELD scores (p = 0.02, r = 0.24). Left ventricular ejection fraction was significantly lower in decompensated patients as compared to compensated patients(p = 0.02).. We did not identify any association between severity of liver disease and cardiac dysfunction. Therefore, a transthoracic echocardiography should be performed in all cirrhotic patients before interventional and surgical procedures regardless of the severity of liver disease.

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来源期刊
Libyan Journal of Medicine
Libyan Journal of Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.20%
发文量
20
审稿时长
>12 weeks
期刊介绍: Libyan Journal of Medicine (LJM) is a peer-reviewed, Open Access, international medical journal aiming to promote heath and health education by publishing high-quality medical research in the different disciplines of medicine. LJM was founded in 2006 by a group of enthusiastic Libyan medical scientists who looked at the contribution of Libyan publications to the international medical literature and saw that a publication outlet was missing. To fill this gap they launched LJM as a tool for transferring current medical knowledge to and from colleagues in developing countries, particularly African countries, as well as internationally.The journal is still led by a group of Libyan physicians inside and outside Libya, but it also enjoys support and recognition from the international medical community.
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