破译发育中的哺乳动物大脑中的细胞间通讯。

Neurogenesis (Austin, Tex.) Pub Date : 2017-02-06 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1286425
Scott A Yuzwa, Freda D Miller
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引用次数: 3

摘要

构成哺乳动物大脑皮层的神经元的不同亚型是在胚胎神经发生期间由单一种群的皮层神经前体细胞产生的。虽然神经发生过程在转录和翻译水平上受到严格控制,但存在大量的外部或生态位控制神经发生过程的机会。在我们最近发表的工作中,我们结合了计算和生物学方法来表征皮层神经元和皮层前体细胞之间的细胞间通信,从而揭示了一个意想不到的复杂生长因子通信网络,该网络准确地预测了皮层神经发生的新调节因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Deciphering cell-cell communication in the developing mammalian brain.

The diverse subtypes of neurons that comprise the mammalian cerebral cortex are produced from a single population of cortical neural precursor cells during the period of embryonic neurogenesis. While this process of neurogenesis is tightly controlled at the transcriptional and translational levels, substantial opportunity exists for extrinsic or niche control of the process of neurogenesis. In our recently published work we made use of a combination of computational and biologic approaches to characterize cell-cell communication between cortical neurons and cortical precursor cells and thereby reveal an unexpectedly complex growth factor communication network that accurately predicted new regulators of cortical neurogenesis.

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