Emmanuel Omamurhomu Olose, John Edet, Monday Nwite Igwe, Donald Chidozie Chukwujekwu, Miriam Chinyere Aguocha, Richard Uwakwe
{"title":"尼日利亚埃努古地区服用抗精神病药物的精神分裂症患者的血脂异常和医疗结果(健康相关的生活质量)","authors":"Emmanuel Omamurhomu Olose, John Edet, Monday Nwite Igwe, Donald Chidozie Chukwujekwu, Miriam Chinyere Aguocha, Richard Uwakwe","doi":"10.1155/2017/9410575","DOIUrl":null,"url":null,"abstract":"<p><p><i>Aim</i>. Determine association between use (and type) of antipsychotics and dyslipidaemia in newly diagnosed schizophrenia patients attending Federal Neuropsychiatric Hospital, Enugu. <i>Methods</i>. From sixty antipsychotic naive patients with schizophrenia and sixty first-degree relatives matched for gender and age, fasting blood lipid profiles were measured at baseline and after twelve weeks. Medical Outcome Study Short Form General Health Survey was administered to patients on both occasions. Fasting lipid profile changes of both groups were compared. <i>Results</i>. Mean endpoint of total cholesterol (TC), low density lipoprotein (LD), and triglycerides (TG) in mmol/l for cases was significantly higher than initial values (TC 4.5 versus 4.3, <i>t</i> = 4.3, <i>p</i> < 0.0001), (LDL 2.8 versus 2.6, <i>t</i> = 14.3, <i>p</i> < 0.0001), and (TG 1.3 versus 1.0, <i>t</i> = 12.1, <i>p</i> < 0.0001). Mean endpoint of high density lipoprotein (HDL) in mmol/l for cases was significantly lower than initial values (1.1 versus 1.2, <i>t</i> = 12.1, <i>p</i> < 0.0001). Prevalence of dyslipidaemia for cases was 13%. Mean endpoint of TC, LDL, TG, and HDL in mmol/l for controls was not significantly different from initial values (TC 4.30 versus 4.27, <i>t</i> = 1.09, <i>p</i> = 0.279), (LDL 2.49 versus 2.46, <i>t</i> = 1.28, <i>p</i> = 0.205), (TG 0.96 versus 0.94, <i>t</i> = 1.27, <i>p</i> = 0.207), and (HDL 1.37 versus 1.38, <i>t</i> = 1.61, <i>p</i> = 0.113). Subjects on atypical antipsychotics had higher risk for dyslipidaemia. <i>Conclusion</i>. Use of antipsychotics was significantly associated with dyslipidaemia.</p>","PeriodicalId":30537,"journal":{"name":"Psychiatry Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9410575","citationCount":"5","resultStr":"{\"title\":\"Dyslipidaemia and Medical Outcome (Health Related Quality of Life) in Patients with Schizophrenia Taking Antipsychotics in Enugu, Nigeria.\",\"authors\":\"Emmanuel Omamurhomu Olose, John Edet, Monday Nwite Igwe, Donald Chidozie Chukwujekwu, Miriam Chinyere Aguocha, Richard Uwakwe\",\"doi\":\"10.1155/2017/9410575\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Aim</i>. Determine association between use (and type) of antipsychotics and dyslipidaemia in newly diagnosed schizophrenia patients attending Federal Neuropsychiatric Hospital, Enugu. <i>Methods</i>. From sixty antipsychotic naive patients with schizophrenia and sixty first-degree relatives matched for gender and age, fasting blood lipid profiles were measured at baseline and after twelve weeks. Medical Outcome Study Short Form General Health Survey was administered to patients on both occasions. Fasting lipid profile changes of both groups were compared. <i>Results</i>. Mean endpoint of total cholesterol (TC), low density lipoprotein (LD), and triglycerides (TG) in mmol/l for cases was significantly higher than initial values (TC 4.5 versus 4.3, <i>t</i> = 4.3, <i>p</i> < 0.0001), (LDL 2.8 versus 2.6, <i>t</i> = 14.3, <i>p</i> < 0.0001), and (TG 1.3 versus 1.0, <i>t</i> = 12.1, <i>p</i> < 0.0001). Mean endpoint of high density lipoprotein (HDL) in mmol/l for cases was significantly lower than initial values (1.1 versus 1.2, <i>t</i> = 12.1, <i>p</i> < 0.0001). Prevalence of dyslipidaemia for cases was 13%. Mean endpoint of TC, LDL, TG, and HDL in mmol/l for controls was not significantly different from initial values (TC 4.30 versus 4.27, <i>t</i> = 1.09, <i>p</i> = 0.279), (LDL 2.49 versus 2.46, <i>t</i> = 1.28, <i>p</i> = 0.205), (TG 0.96 versus 0.94, <i>t</i> = 1.27, <i>p</i> = 0.207), and (HDL 1.37 versus 1.38, <i>t</i> = 1.61, <i>p</i> = 0.113). Subjects on atypical antipsychotics had higher risk for dyslipidaemia. <i>Conclusion</i>. Use of antipsychotics was significantly associated with dyslipidaemia.</p>\",\"PeriodicalId\":30537,\"journal\":{\"name\":\"Psychiatry Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2017/9410575\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatry Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2017/9410575\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/2/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2017/9410575","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/2/20 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
摘要
的目标。确定在埃努古联邦神经精神病院新诊断的精神分裂症患者抗精神病药物的使用(和类型)与血脂异常之间的关系方法。从60名抗精神病的精神分裂症患者和60名性别和年龄匹配的一级亲属中,在基线和12周后测量空腹血脂谱。在这两种情况下,对患者进行了简短的医疗结果研究一般健康调查。比较两组空腹血脂变化。结果。总胆固醇(TC)、低密度脂蛋白(LD)和甘油三酯(TG) (mmol/l)的平均终点显著高于初始值(TC 4.5 vs 4.3, t = 4.3, p < 0.0001), (LDL 2.8 vs 2.6, t = 14.3, p < 0.0001)和(TG 1.3 vs 1.0, t = 12.1, p < 0.0001)。病例高密度脂蛋白(HDL)的平均终点(mmol/l)显著低于初始值(1.1 vs 1.2, t = 12.1, p < 0.0001)。病例中血脂异常的患病率为13%。对照组TC、LDL、TG和HDL (mmol/l)的平均终点与初始值无显著差异(TC 4.30 vs 4.27, t = 1.09, p = 0.279), LDL 2.49 vs 2.46, t = 1.28, p = 0.205), TG 0.96 vs 0.94, t = 1.27, p = 0.207), HDL 1.37 vs 1.38, t = 1.61, p = 0.113)。服用非典型抗精神病药物的受试者患血脂异常的风险较高。结论。抗精神病药物的使用与血脂异常显著相关。
Dyslipidaemia and Medical Outcome (Health Related Quality of Life) in Patients with Schizophrenia Taking Antipsychotics in Enugu, Nigeria.
Aim. Determine association between use (and type) of antipsychotics and dyslipidaemia in newly diagnosed schizophrenia patients attending Federal Neuropsychiatric Hospital, Enugu. Methods. From sixty antipsychotic naive patients with schizophrenia and sixty first-degree relatives matched for gender and age, fasting blood lipid profiles were measured at baseline and after twelve weeks. Medical Outcome Study Short Form General Health Survey was administered to patients on both occasions. Fasting lipid profile changes of both groups were compared. Results. Mean endpoint of total cholesterol (TC), low density lipoprotein (LD), and triglycerides (TG) in mmol/l for cases was significantly higher than initial values (TC 4.5 versus 4.3, t = 4.3, p < 0.0001), (LDL 2.8 versus 2.6, t = 14.3, p < 0.0001), and (TG 1.3 versus 1.0, t = 12.1, p < 0.0001). Mean endpoint of high density lipoprotein (HDL) in mmol/l for cases was significantly lower than initial values (1.1 versus 1.2, t = 12.1, p < 0.0001). Prevalence of dyslipidaemia for cases was 13%. Mean endpoint of TC, LDL, TG, and HDL in mmol/l for controls was not significantly different from initial values (TC 4.30 versus 4.27, t = 1.09, p = 0.279), (LDL 2.49 versus 2.46, t = 1.28, p = 0.205), (TG 0.96 versus 0.94, t = 1.27, p = 0.207), and (HDL 1.37 versus 1.38, t = 1.61, p = 0.113). Subjects on atypical antipsychotics had higher risk for dyslipidaemia. Conclusion. Use of antipsychotics was significantly associated with dyslipidaemia.