认知正常和低于正常范围的精神分裂症中网络相关区域皮质变薄。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI:10.1155/2017/9760905
R Walter Heinrichs, Farena Pinnock, Melissa Parlar, Colin Hawco, Lindsay Hanford, Geoffrey B Hall
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引用次数: 8

摘要

这项研究评估了在默认模式、显著性和中央执行网络方面,跨越大脑和区域的皮质厚度是否能区分精神分裂症患者和具有正常范围或低于正常范围认知表现的健康对照。认知正态性采用matrix共识认知电池(MCCB)综合评分(T = 50±10)进行定义,并采用结构磁共振成像生成皮层厚度数据。全脑分析显示,认知范围正常的对照组(n = 39)比认知范围正常(n = 17)和低于正常范围(n = 49)的患者有更大的皮质厚度。认知正常的对照组在与默认模式和显著性相关的区域也比患者表现出更大的厚度,但在中央执行网络中没有。在认知正常范围和低于正常范围的对照组(n = 24)或认知正常和低于正常范围的患者之间,没有发现任何厚度测量的差异。此外,网络区域之间的结构协方差很高,并且在亚群之间相似。阳性和阴性症状严重程度与厚度值无关。与默认网络和突出网络相关的大脑皮层变薄可能反映了精神分裂症的精神病性精神病理的共同方面,而与认知障碍无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia.

This study assessed whether cortical thickness across the brain and regionally in terms of the default mode, salience, and central executive networks differentiates schizophrenia patients and healthy controls with normal range or below-normal range cognitive performance. Cognitive normality was defined using the MATRICS Consensus Cognitive Battery (MCCB) composite score (T = 50 ± 10) and structural magnetic resonance imaging was used to generate cortical thickness data. Whole brain analysis revealed that cognitively normal range controls (n = 39) had greater cortical thickness than both cognitively normal (n = 17) and below-normal range (n = 49) patients. Cognitively normal controls also demonstrated greater thickness than patients in regions associated with the default mode and salience, but not central executive networks. No differences on any thickness measure were found between cognitively normal range and below-normal range controls (n = 24) or between cognitively normal and below-normal range patients. In addition, structural covariance between network regions was high and similar across subgroups. Positive and negative symptom severity did not correlate with thickness values. Cortical thinning across the brain and regionally in relation to the default and salience networks may index shared aspects of the psychotic psychopathology that defines schizophrenia with no relation to cognitive impairment.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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