神经依赖性再生研究简史。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-10 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1302216
Johanna E Farkas, James R Monaghan
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引用次数: 49

摘要

神经依赖是一种在大量物种和组织中观察到的现象。从斑马鱼到胎鼠再到人类,各种动物模型的研究表明,神经对组织修复和再生的支持至关重要。尽管对这种现象的研究已经持续了几个世纪,主要是通过对蝾螈的研究,但神经依赖的细胞和分子机制仍然知之甚少。在这里,我们强调了脊椎动物神经依赖的近普遍性和临床相关性,同时提供了其研究的时间表和对理解这一过程背后机制的最新进展的概述。在介绍神经依赖研究的简史时,我们提供了历史和现代背景,以我们最近在墨西哥蝾螈神经依赖肢体再生方面的工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A brief history of the study of nerve dependent regeneration.

Nerve dependence is a phenomenon observed across a stunning array of species and tissues. From zebrafish to fetal mice to humans, research across various animal models has shown that nerves are critical for the support of tissue repair and regeneration. Although the study of this phenomenon has persisted for centuries, largely through research conducted in salamanders, the cellular and molecular mechanisms of nerve dependence remain poorly-understood. Here we highlight the near-ubiquity and clinical relevance of vertebrate nerve dependence while providing a timeline of its study and an overview of recent advancements toward understanding the mechanisms behind this process. In presenting a brief history of the research of nerve dependence, we provide both historical and modern context to our recent work on nerve dependent limb regeneration in the Mexican axolotl.

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