雌雄易位的雄性姐妹染色单体交换。

Merlin G Butler
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引用次数: 0

摘要

姐妹染色单体交换(SCE)被认为是遗传损伤和早期染色体改变的指标。测定了一名27岁的白人男性不育患者的SCE频率,该患者身高高,Y染色体有一条短臂和两条长臂的非双中心Y/Y易位。10例对照的SCE频率为8.4±SD 0.51,对照组的SCE频率为7.9±SD 1.4。对SCE数据进行双尾t检验,发现Y/Y易位个体与对照组之间无显著差异。显然,与10个两性对照对象相比,这条改变的染色体不会干扰染色体的总体行为和产生的sce数量。
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Sister Chromatid Exchanges in A Male With A Y/Y Translocation.

Sister chromatid exchanges (SCE) are considered indicators of genetic damage and early chromosome changes. The SCE frequency from an infertile 27-year-old, white male with tall stature and a nondicentric Y/Y translocation consisting of one short arm and two long arms of the Y chromosome was determined. The SCE frequency was 7.9 ± SD 1.4 while the SCE frequency from ten control subjects was 8.4 ± SD 0.51. A two-tailed t-test was applied to the SCE data and no significant difference was found between the individual with the Y/Y translocation and control subjects. Apparently, this altered chromosome does not interfere with the total chromosome behavior and the number of SCEs produced when compared to ten control subjects of both sexes.

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