人对急性吸烟的原位细胞因子和白细胞反应。

IF 2.4 4区 医学 Q3 TOXICOLOGY Journal of Immunotoxicology Pub Date : 2017-12-01 DOI:10.1080/1547691X.2017.1332699
Tegan Kastelein, Rob Duffield, Frank Marino
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引用次数: 9

摘要

本研究检测了不同吸烟史的吸烟者急性吸烟后的免疫/炎症参数。将28名男性习惯性吸烟者按吸烟史分为青年吸烟者(YSM)和中年吸烟者(MSM)。参与者根据健康和吸烟习惯进行匹配,并遵循基线测试,进行吸烟协议,包括在15分钟内吸两支烟。在治疗前和治疗后1小时和4小时采集静脉血,分析白细胞介素(IL)-6、IL-1β、IL-1ra、单核细胞趋化蛋白-1 (MCP-1)、c反应蛋白(CRP)和白细胞的循环水平。各组间IL-1ra、IL-1β或白细胞无基线差异。MCP-1和IL-6水平显著高于对照组(p
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Human in situ cytokine and leukocyte responses to acute smoking.

This study examined immune/inflammatory parameters following an acute tobacco smoking episode in smokers with varying smoking histories. Twenty-eight male habitual smokers were categorized according to smoking history, e.g. younger smoker (YSM) or middle-aged smoker (MSM). Participants were matched for fitness and smoking habits and following baseline testing, undertook a smoking protocol involving consumption of two cigarettes within 15 min. Venous blood was collected pre- and immediately, 1 h, and 4 h post-protocol to permit analyses of circulating levels of interleukin (IL)-6, IL-1β, IL-1ra, monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP), and leukocytes. No baseline differences were observed between groups for IL-1ra, IL-1β, or leukocytes. MCP-1 and IL-6 levels were significantly (p < 0.05) elevated at baseline in YSM. Both groups showed an increase in MCP-1 levels from pre- to immediately post-cigarette consumption. The MSM also displayed an increase in IL-6 post-smoking, followed by a decline over the period from 1 to 4 h thereafter. A significant decline in circulating lymphocyte and eosinophil levels from immediately post-cigarette consumption to 1 h later was observed in both groups. Monocyte levels in the YSM followed a similar profile but no significant effects on this cell type were evident in the MSM. From these results, a 10-year difference in smoking history induces mild leukopenia. Altered responses due to smoking were also evident with respect to levels of circulating biomarkers, which may be indicative of an effect of differences in cumulative smoking history.

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来源期刊
Journal of Immunotoxicology
Journal of Immunotoxicology 医学-毒理学
CiteScore
6.70
自引率
3.00%
发文量
26
审稿时长
1 months
期刊介绍: The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.
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