Soha M. Hamdy , Amany M. Shabaan , Abdel Karim M. Abdel Latif , Ayman M. Abdel-Aziz , Alshimaa M. Amin
{"title":"橙皮苷和虎果对雌性大鼠丙烯酰胺毒性的保护作用","authors":"Soha M. Hamdy , Amany M. Shabaan , Abdel Karim M. Abdel Latif , Ayman M. Abdel-Aziz , Alshimaa M. Amin","doi":"10.1016/j.etp.2017.05.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Phytochemicals<span> that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin<span><span> and tiger nut against the early changes that may be related to the toxicity of </span>acrylamide<span> in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI). There was a significant increase in the levels of serum carcino embryonic antigen (CEA), </span></span></span></span>malondialdehyde<span><span><span><span><span> (MDA), protein carbonyls (CO), ALT, AST, LDH, urea and creatinine while no significant changes of serum total </span>sialic acid<span>, progesterone (prog) and </span></span>estradiol<span> (E2) levels, and significant decreases of body weights, catalase<span> (Cat) activity, superoxide dismutase (SOD) activity, </span></span></span>reduced glutathione (GSH) level, and </span>glutathione peroxidase<span> (GSH-Px) activity of ACR treated group compared with the control. Our results suggested that supplementation of a diet with hesperidin provided antioxidant defense more significant than tiger nut against the toxicity of ACR in breast, liver and kidney tissues.</span></span></p></div>","PeriodicalId":50465,"journal":{"name":"Experimental and Toxicologic Pathology","volume":"69 8","pages":"Pages 580-588"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etp.2017.05.004","citationCount":"37","resultStr":"{\"title\":\"Protective effect of Hesperidin and Tiger nut against Acrylamide toxicity in female rats\",\"authors\":\"Soha M. Hamdy , Amany M. Shabaan , Abdel Karim M. Abdel Latif , Ayman M. Abdel-Aziz , Alshimaa M. Amin\",\"doi\":\"10.1016/j.etp.2017.05.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Phytochemicals<span> that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin<span><span> and tiger nut against the early changes that may be related to the toxicity of </span>acrylamide<span> in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI). There was a significant increase in the levels of serum carcino embryonic antigen (CEA), </span></span></span></span>malondialdehyde<span><span><span><span><span> (MDA), protein carbonyls (CO), ALT, AST, LDH, urea and creatinine while no significant changes of serum total </span>sialic acid<span>, progesterone (prog) and </span></span>estradiol<span> (E2) levels, and significant decreases of body weights, catalase<span> (Cat) activity, superoxide dismutase (SOD) activity, </span></span></span>reduced glutathione (GSH) level, and </span>glutathione peroxidase<span> (GSH-Px) activity of ACR treated group compared with the control. Our results suggested that supplementation of a diet with hesperidin provided antioxidant defense more significant than tiger nut against the toxicity of ACR in breast, liver and kidney tissues.</span></span></p></div>\",\"PeriodicalId\":50465,\"journal\":{\"name\":\"Experimental and Toxicologic Pathology\",\"volume\":\"69 8\",\"pages\":\"Pages 580-588\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.etp.2017.05.004\",\"citationCount\":\"37\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and Toxicologic Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0940299317300957\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and Toxicologic Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0940299317300957","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Protective effect of Hesperidin and Tiger nut against Acrylamide toxicity in female rats
Phytochemicals that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the early changes that may be related to the toxicity of acrylamide in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI). There was a significant increase in the levels of serum carcino embryonic antigen (CEA), malondialdehyde (MDA), protein carbonyls (CO), ALT, AST, LDH, urea and creatinine while no significant changes of serum total sialic acid, progesterone (prog) and estradiol (E2) levels, and significant decreases of body weights, catalase (Cat) activity, superoxide dismutase (SOD) activity, reduced glutathione (GSH) level, and glutathione peroxidase (GSH-Px) activity of ACR treated group compared with the control. Our results suggested that supplementation of a diet with hesperidin provided antioxidant defense more significant than tiger nut against the toxicity of ACR in breast, liver and kidney tissues.
期刊介绍：
Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.
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