神经系统的发育依赖于内体运输。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-27 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1316887
Ivan Mestres, Ching-Hwa Sung
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引用次数: 2

摘要

越来越多的发现揭示了内体机制在神经系统发育中的重要作用。内体与神经发生过程中不对称分裂祖细胞中决定细胞命运的分子的差异分离有关。此外,通过内吞运输,膜组分的精确移除和重新插入调节了信号受体和粘附分子的时空分布,这决定了迁移神经元的形态和运动性。新出现的证据表明,内体分选接头的作用取决于细胞类型和发育阶段。在这些过程中,由核内体分类的信号受体和/或粘附分子的库仍有待探索。在这篇评论中,我们将简要介绍这一研究领域的进展。
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Nervous system development relies on endosomal trafficking.

Accumulating findings have begun to unveil the important role of the endosomal machinery in the nervous system development. Endosomes have been linked to the differential segregation of cell fate determining molecules in asymmetrically dividing progenitors during neurogenesis. Additionally, the precise removal and reinsertion of membrane components through endocytic trafficking regulates the spatial and temporal distribution of signaling receptors and adhesion molecules, which determine the morphology and motility of migrating neurons. Emerging evidence suggests that the role of the endosomal sorting adaptors is dependent upon cell type and developmental stage. The repertoire of the signaling receptors and/or adhesion molecules sorted by the endosome during these processes remains to be explored. In this commentary, we will briefly address the progress in this research field.

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