基于主成分分析的遗传关联检验。

Pub Date : 2017-07-26 DOI:10.1515/sagmb-2016-0061

Zhongxue Chen, Shizhong Han, Kai Wang

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引用次数: 10

摘要

文献中提出了许多基于基因和通路的关联测试。其中，SKAT被广泛应用于罕见变异体关联研究。在本文中，我们研究了SKAT和主成分分析之间的联系。这项调查导致了一个程序，包括SKAT作为一个特殊情况。通过仿真研究和实际数据应用，将该方法与现有的一些测试方法进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genetic association test based on principal component analysis.

Many gene- and pathway-based association tests have been proposed in the literature. Among them, the SKAT is widely used, especially for rare variants association studies. In this paper, we investigate the connection between SKAT and a principal component analysis. This investigation leads to a procedure that encompasses SKAT as a special case. Through simulation studies and real data applications, we compare the proposed method with some existing tests.

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