behaperet病的遗传和免疫功能障碍及免疫调节治疗方法。

IF 2.4 4区 医学 Q3 TOXICOLOGY Journal of Immunotoxicology Pub Date : 2017-12-01 DOI:10.1080/1547691X.2017.1346008
Arash Salmaninejad, Arezoo Gowhari, Seyedmojtaba Hosseini, Saeed Aslani, Meysam Yousefi, Tayyeb Bahrami, Masoume Ebrahimi, Abolfazl Nesaei, Masoud Zal
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引用次数: 27

摘要

behet病(BD)是一种慢性自身免疫性疾病,主要流行于地中海沿岸人群。BD的确切病因尚未完全解释,但疾病的发生与遗传因素人类白细胞抗原(HLA)-B51抗原有关。在BD患者中发现的各种免疫功能障碍中,中性粒细胞运动性和超氧化物的产生增加,肿瘤坏死因子(TNF)-α的产生升高,白细胞介素(IL)-10的产生减少。炎性细胞因子如IL-1和IL-17在BD中的升高与microRNA的异常表达有关。在BD患者中已经观察到参与病原体反应的分子中的基因多态性,这些分子最终可以调节宿主的抗菌反应。此外,在编码趋化因子和粘附分子的基因中已经报道了几个单核苷酸多态性(snp);许多这些变化表现为血管炎症和血管损伤的增加。最后,遗传和表观遗传改变被认为参与了双相障碍的发病机制。在双相障碍患者的单核细胞和淋巴细胞中发现DNA甲基化的改变,导致这些细胞的不良功能。本文综述了有关双相障碍的免疫功能障碍、遗传学、新描述的临床特征和基于当前对双相障碍的理解使用免疫调节剂的新治疗策略的文献。
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Genetics and immunodysfunction underlying Behçet's disease and immunomodulant treatment approaches.

Behçet's disease (BD) is a chronic autoimmune condition primarily prevalent in populations along the Mediterranean Sea. The exact etiology of BD has not been fully explained yet, but the disease occurrence is associated with a genetic factor, human leukocyte antigen (HLA)-B51 antigen. Among the various immunodysfunctions that are found in BD, patients are increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin (IL)-10. Elevated levels of inflammatory cytokines like IL-1 and IL-17 in BD have been found associated with aberrant expression of microRNA. Gene polymorphisms in BD patients have been observed in molecules involved in responses to pathogens that can ultimately modulate the host antimicrobial response. Moreover, several single nucleotide polymorphisms (SNPs) have been reported in genes encoding chemokines and adhesion molecules; many of these changes manifest as increases in vascular inflammation and vascular damage. Lastly, genetic and epigenetic changes have been suggested as involved in the pathogenesis of BD. Modifications in DNA methylation have been found in BD patient monocytes and lymphocytes, leading to adverse function of these cells. This review presents a comprehensive compilation of the literature with regard to the immunodysfunction underlying BD, as well as of the genetics, newly described clinical specifications and novel treatment strategies using immunomodulants based on the current understanding of BD.

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来源期刊
Journal of Immunotoxicology
Journal of Immunotoxicology 医学-毒理学
CiteScore
6.70
自引率
3.00%
发文量
26
审稿时长
1 months
期刊介绍: The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.
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