伴有和不伴有人类免疫缺陷病毒感染的结核病患者的脂质特征。

International Journal of Chronic Diseases Pub Date : 2017-01-01 Epub Date: 2017-11-01 DOI:10.1155/2017/3843291
Gebremedhin Gebremicael, Yemane Amare, Feyissa Challa, Atsbeha Gebreegziabxier, Girmay Medhin, Mistire Wolde, Desta Kassa
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引用次数: 17

摘要

背景:了解之前的低血脂是导致活动性结核病(TB)还是活动性结核病导致低血脂是至关重要的。方法:对159名研究对象进行脂质谱测定,包括93例活动性结核患者[44例HIV合并感染(HIV+TB+)和49例HIV阴性(HIV-TB+)]、41例结核菌素皮肤试验(TST)阳性病例[17例HIV合并感染(HIV+TST+)和24例HIV阴性(HIV-TST+)]和25例健康对照(HIV-TST-)。采用Cobas Integra 400 Plus测定脂质谱浓度水平。结果:HIV-TB+患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)浓度明显低于HIV-TST+和HIV-TST-个体。同样,HIV+TB+患者的TC、LDL-C和HDL-C浓度明显低于HIV-TB+患者。抗结核治疗(ATT) 6个月后,HIV-TB+患者TC、LDL-C、HDL-C浓度水平较基线水平升高,但与HIV-TST+患者浓度差异无统计学意义。结论:结核病患者脂质谱低浓度可能是结核病的结果,治疗后明显升高。
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Lipid Profile in Tuberculosis Patients with and without Human Immunodeficiency Virus Infection.

Background: Understanding whether the preceding low lipid profile leads to active tuberculosis (TB) or active TB leads to low lipid profile is crucial.

Methods: Lipid profile concentrations were determined from 159 study participants composed of 93 active TB patients [44 HIV coinfected (HIV+TB+) and 49 HIV negative (HIV-TB+)], 41 tuberculin skin test (TST) positive cases [17 HIV coinfected (HIV+TST+) and 24 HIV negative (HIV-TST+)], and 25 healthy controls (HIV-TST-). Cobas Integra 400 Plus was used to determine lipid profiles concentration level.

Results: The concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in HIV-TB+ patients were significantly lower compared to HIV-TST+ and to HIV-TST- individuals. Similarly, the concentrations of the TC, LDL-C, and HDL-C in HIV+TB+ were significantly lower compared to HIV-TB+ patients. After the 6 months of anti-TB treatment (ATT), the concentration levels of TC, LDL-C, and HDL-C in HIV-TB+ patients were higher compared to the baseline concentration levels, while they were not significantly different compared to that of HIV-TST+ concentration.

Conclusion: The low concentration of lipid profiles in TB patients may be a consequence of the disease and significantly increased in TB patients after treatment.

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