严重出血性低血压对鸡血管系统的影响。

J M Ploucha, S J Bursian, R K Ringer, J B Scott
{"title":"严重出血性低血压对鸡血管系统的影响。","authors":"J M Ploucha, S J Bursian, R K Ringer, J B Scott","doi":"10.3181/00379727-170-41412","DOIUrl":null,"url":null,"abstract":"Abstract We have recently reported that hemorrhage to a mean arterial blood pressure (MABP) of 50 mm Hg in the chicken has no effect on total peripheral resistance or skeletal muscle vascular resistance (judged from changes in limb perfusion pressure (Pp) during constant blood flow). In the present study we report the effect of a more severe hemorrhagic hypotension (MABP = 25 mm Hg) on skeletal muscle vascular resistance in the constantly perfused hindlimb of the chicken following severance of the sciatic nerve trunk, bilateral cervical vagotomy, α-adrenergic blockade, or during artificial perfusion of the head with arterial blood. Concentrations of serotonin (SER), dopamine (DA), and norepinephrine (NE) in plasma were determined at different levels of hypotension. While hemorrhage to MABP = 50 mm Hg had no effect on P p, a further hemorrhage to MABP = 25 mm Hg produced a sharp rise in P p which was unaffected by severance of the sciatic nerve truck or bilateral cervical vagotomy. This vasoconstriction could be completely climinated by intraarterial infusion of phentolamine or by pump perfusing the head during the hypotensive interval. Furthermore, concentrations of SER, DA, and NE were significantly elevated only when the rise in P p was evident. We conclude that the vasoconstrictor response to severe hemorrhagic hypotension in the chicken is primarily mediated by an increase in circulating catecholamines due to cerebral ischemia, rather than a baroreflex.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"160-4"},"PeriodicalIF":0.0000,"publicationDate":"1982-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-170-41412","citationCount":"5","resultStr":"{\"title\":\"Effects of severe hemorrhagic hypotension on the vasculature of the chicken.\",\"authors\":\"J M Ploucha, S J Bursian, R K Ringer, J B Scott\",\"doi\":\"10.3181/00379727-170-41412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract We have recently reported that hemorrhage to a mean arterial blood pressure (MABP) of 50 mm Hg in the chicken has no effect on total peripheral resistance or skeletal muscle vascular resistance (judged from changes in limb perfusion pressure (Pp) during constant blood flow). In the present study we report the effect of a more severe hemorrhagic hypotension (MABP = 25 mm Hg) on skeletal muscle vascular resistance in the constantly perfused hindlimb of the chicken following severance of the sciatic nerve trunk, bilateral cervical vagotomy, α-adrenergic blockade, or during artificial perfusion of the head with arterial blood. Concentrations of serotonin (SER), dopamine (DA), and norepinephrine (NE) in plasma were determined at different levels of hypotension. While hemorrhage to MABP = 50 mm Hg had no effect on P p, a further hemorrhage to MABP = 25 mm Hg produced a sharp rise in P p which was unaffected by severance of the sciatic nerve truck or bilateral cervical vagotomy. This vasoconstriction could be completely climinated by intraarterial infusion of phentolamine or by pump perfusing the head during the hypotensive interval. Furthermore, concentrations of SER, DA, and NE were significantly elevated only when the rise in P p was evident. We conclude that the vasoconstrictor response to severe hemorrhagic hypotension in the chicken is primarily mediated by an increase in circulating catecholamines due to cerebral ischemia, rather than a baroreflex.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"160-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-170-41412\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-170-41412\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-170-41412","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Effects of severe hemorrhagic hypotension on the vasculature of the chicken.
Abstract We have recently reported that hemorrhage to a mean arterial blood pressure (MABP) of 50 mm Hg in the chicken has no effect on total peripheral resistance or skeletal muscle vascular resistance (judged from changes in limb perfusion pressure (Pp) during constant blood flow). In the present study we report the effect of a more severe hemorrhagic hypotension (MABP = 25 mm Hg) on skeletal muscle vascular resistance in the constantly perfused hindlimb of the chicken following severance of the sciatic nerve trunk, bilateral cervical vagotomy, α-adrenergic blockade, or during artificial perfusion of the head with arterial blood. Concentrations of serotonin (SER), dopamine (DA), and norepinephrine (NE) in plasma were determined at different levels of hypotension. While hemorrhage to MABP = 50 mm Hg had no effect on P p, a further hemorrhage to MABP = 25 mm Hg produced a sharp rise in P p which was unaffected by severance of the sciatic nerve truck or bilateral cervical vagotomy. This vasoconstriction could be completely climinated by intraarterial infusion of phentolamine or by pump perfusing the head during the hypotensive interval. Furthermore, concentrations of SER, DA, and NE were significantly elevated only when the rise in P p was evident. We conclude that the vasoconstrictor response to severe hemorrhagic hypotension in the chicken is primarily mediated by an increase in circulating catecholamines due to cerebral ischemia, rather than a baroreflex.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Thiosulfate pharmacokinetics in normal and anuric dogs. Effect of phagocytosed fat and casein on the intraphagosomal pH in bovine polymorphonuclear leukocytes. Determinants of protection by human immune globulin against experimental herpes neonatorum. Plasma calcium, plasma and thyroidal calcitonin, and histomorphometric bone changes in parathyroidectomized rats. Effects of ovarian steroids on luteal function: prevention of luteolysis following LH-neutralization in the pseudopregnant rat.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1