Sabrina Paganoni, Erin McDonnell, David Schoenfeld, Hong Yu, Jing Deng, Hamza Atassi, Alexander Sherman, Padmaja Yerramilli-Rao, Merit Cudkowicz, Nazem Atassi
{"title":"肌萎缩性侧索硬化症(ALS)的功能衰退与绝望有关。","authors":"Sabrina Paganoni, Erin McDonnell, David Schoenfeld, Hong Yu, Jing Deng, Hamza Atassi, Alexander Sherman, Padmaja Yerramilli-Rao, Merit Cudkowicz, Nazem Atassi","doi":"10.4172/2155-9562.1000423","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the relationships between hopelessness, depression, quality of life, and disease progression in ALS.</p><p><strong>Methods: </strong>Hopelessness and depression were assessed prospectively in a cohort of people with ALS using the Beck Hopelessness scale (BHS) and the ALS Depression Inventory (ADI-12), respectively. ALS Specific Quality of Life and measures of functional status (ALSFRS-R and forced vital capacity) were collected. Associations between changes in psychological health and functional scores were calculated using Spearman correlation coefficients.</p><p><strong>Results: </strong>Twenty-five people with ALS had at least 2 visits and were followed for a mean of 11 (± 6) months. People with hopelessness and depression reported worse quality of life (p<0.01 for both associations). Decline in function between any two visits measured by ALSFRS-R (p<0.01) and FVC (p=0.02) correlated with increased hopelessness, but not depression.</p><p><strong>Conclusion: </strong>This study highlights the importance of monitoring hopelessness in ALS, particularly in patients with faster functional decline.</p>","PeriodicalId":16495,"journal":{"name":"Journal of neurology & neurophysiology","volume":"8 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-9562.1000423","citationCount":"16","resultStr":"{\"title\":\"Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).\",\"authors\":\"Sabrina Paganoni, Erin McDonnell, David Schoenfeld, Hong Yu, Jing Deng, Hamza Atassi, Alexander Sherman, Padmaja Yerramilli-Rao, Merit Cudkowicz, Nazem Atassi\",\"doi\":\"10.4172/2155-9562.1000423\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the relationships between hopelessness, depression, quality of life, and disease progression in ALS.</p><p><strong>Methods: </strong>Hopelessness and depression were assessed prospectively in a cohort of people with ALS using the Beck Hopelessness scale (BHS) and the ALS Depression Inventory (ADI-12), respectively. ALS Specific Quality of Life and measures of functional status (ALSFRS-R and forced vital capacity) were collected. Associations between changes in psychological health and functional scores were calculated using Spearman correlation coefficients.</p><p><strong>Results: </strong>Twenty-five people with ALS had at least 2 visits and were followed for a mean of 11 (± 6) months. People with hopelessness and depression reported worse quality of life (p<0.01 for both associations). Decline in function between any two visits measured by ALSFRS-R (p<0.01) and FVC (p=0.02) correlated with increased hopelessness, but not depression.</p><p><strong>Conclusion: </strong>This study highlights the importance of monitoring hopelessness in ALS, particularly in patients with faster functional decline.</p>\",\"PeriodicalId\":16495,\"journal\":{\"name\":\"Journal of neurology & neurophysiology\",\"volume\":\"8 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4172/2155-9562.1000423\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of neurology & neurophysiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2155-9562.1000423\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neurology & neurophysiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2155-9562.1000423","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/4/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).
Objective: To determine the relationships between hopelessness, depression, quality of life, and disease progression in ALS.
Methods: Hopelessness and depression were assessed prospectively in a cohort of people with ALS using the Beck Hopelessness scale (BHS) and the ALS Depression Inventory (ADI-12), respectively. ALS Specific Quality of Life and measures of functional status (ALSFRS-R and forced vital capacity) were collected. Associations between changes in psychological health and functional scores were calculated using Spearman correlation coefficients.
Results: Twenty-five people with ALS had at least 2 visits and were followed for a mean of 11 (± 6) months. People with hopelessness and depression reported worse quality of life (p<0.01 for both associations). Decline in function between any two visits measured by ALSFRS-R (p<0.01) and FVC (p=0.02) correlated with increased hopelessness, but not depression.
Conclusion: This study highlights the importance of monitoring hopelessness in ALS, particularly in patients with faster functional decline.
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