异常的N400语义启动效应可能反映精神分裂症的精神病理过程:一项双胞胎研究。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-08-28 DOI:10.1155/2017/7163198
Anuradha Sharma, Heinrich Sauer, Holger Hill, Claudia Kaufmann, Stephan Bender, Matthias Weisbrod
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引用次数: 7

摘要

目的:用N400效应来表征语义网络的激活。我们采用双胞胎研究设计来调查N400效应异常是否反映了精神分裂症的遗传/性状倾向性或与精神病理过程有关。方法:采用稳健线性回归比较36对同卵双胞胎(6对精神分裂症/分裂情感障碍的和谐双胞胎,11对不和谐双胞胎和19对健康对照)在词汇决策任务中的N400和行为启动效应。此外,我们还检验了简短精神病学评定量表(BPRS)得分与N400效应的相关性以及药物状况对该效应的影响。结果:回归结果显示,仅在直接启动条件下,组对N400效应有显著的主效应(p = 0.003)。间接条件和行为启动效应对实验组无显著影响。与对照组作为参照组的计划对比显示,与对照组相比,受影响的和谐双胞胎的N400效应显著降低,而不和谐双胞胎的N400效应与对照组相比有统计学趋势降低。未受影响的双胞胎与对照组没有显著差异。N400效应降低与BPRS评分升高之间存在相关趋势,且N400效应在用药与未用药患者之间无显著差异。结论:N400效应的降低可能反映了精神分裂症的疾病特异性过程,涉及精神分裂症病理中的额颞叶脑网络。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study.

Objective: Activation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia.

Methods: We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task. Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect.

Results: Regression yielded a significant main effect of group on the N400 effect only in the direct priming condition (p = 0.003). Indirect condition and behavioral priming effect showed no significant effect of group. Planned contrasts with the control group as a reference group revealed that affected concordant twins had significantly reduced N400 effect compared to controls, and discordant affected twins had a statistical trend for reduced N400 effect compared to controls. The unaffected twins did not differ significantly from the controls. There was a trend for correlation between reduced N400 effect and higher BPRS scores, and the N400 effect did not differ significantly between medicated and unmedicated patients.

Conclusions: Reduced N400 effect may reflect disease-specific processes in schizophrenia implicating frontotemporal brain network in schizophrenia pathology.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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