尿素作为提高难水溶性抗坏血酸棕榈酸盐溶解度手段的有效性。

International Journal of Medicinal Chemistry Pub Date : 2017-01-01 Epub Date: 2017-11-06 DOI:10.1155/2017/4391078
Yutaka Inoue, Daichi Niiyama, Isamu Murata, Ikuo Kanamoto
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引用次数: 5

摘要

本研究的目的是评价l -抗坏血酸棕榈酸酯(ASCP)和尿素(UR)的复合物。该评价包括差示扫描量热法(DSC)、粉末x射线衍射(PXRD)、扫描电镜(SEM)、近红外光谱(NIR)、溶解度测试、1,1-二苯基-2-苦酰肼(DPPH)自由基清除测试和蘑菇酪氨酸酶抑制测试。理化评价表明ASCP/UR配合物形成的摩尔比为1/12。溶解度试验表明,ASCP/UR配合物的溶解度比ASCP高。DPPH自由基清除试验和蘑菇酪氨酸酶抑制试验表明,ASCP/UR复合物的活性不受复合物形成的影响。这些结果可能与UR的四方晶系转变为六方晶系以及与ASCP的烷基相互作用有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Usefulness of Urea as a Means of Improving the Solubility of Poorly Water-Soluble Ascorbyl Palmitate.

The aim of this study was to evaluate complexes of L-ascorbyl palmitate (ASCP) and urea (UR). This evaluation involved differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), near-infrared spectroscopy (NIR), a solubility test, a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test, and a mushroom tyrosinase inhibition assay. Physicochemical evaluation revealed that ASCP/UR complexes form at a molar ratio of 1/12. The solubility test revealed that ASCP/UR complexes had increased solubility compared to ASCP. The DPPH radical scavenging test and mushroom tyrosinase inhibition assay revealed that the activity of ASCP/UR complexes was not impaired by complex formation. These results are probably due to the tetragonal crystal system of UR changing to a hexagonal crystal system and interaction with the alkyl group of ASCP.

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期刊介绍: International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.
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