NK细胞和γδT细胞对同种异体造血细胞移植术后复发的保护作用。

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2017-12-01 Epub Date: 2017-10-16 DOI:10.1007/s40778-017-0106-4
Moniek A de Witte, Jürgen Kuball, Jeffrey S Miller
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引用次数: 11

摘要

回顾的目的:同种异体干细胞移植(allogeneic stem cell transplantation, allo-HCT)的预后仍然受到复发和并发症的影响。NK细胞和γδT细胞都是通过mhc不受限制的机制起作用的效应物,它们可以靶向转化和感染的细胞,而不会诱导移植物抗宿主病(GVHD)。基于CD34+选择或αβ-TCR消耗的Allo-HCT平台导致GVHD的低级别,NK和γδT细胞的早期免疫重建(IR)和极少使用GVHD预防措施。在这篇综述中,我们将讨论保留和扩大这些重组先天细胞类型的数量、多样性和功能的策略。最近的发现:目前正在评估双膦酸盐、IL-15细胞因子管理、特异性抗体、检查点抑制剂和(基于巨细胞病毒的)疫苗接种以增强IR。所有这些方法都显示出潜在地增强NK和γδT细胞的免疫功能。摘要:快速积累的数据将先天生物学与拟议的临床免疫干预联系起来,将为揭示确定NK细胞和γδT细胞移植物抗肿瘤作用的共享途径提供独特的机会。
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NK Cells and γδT Cells for Relapse Protection After Allogeneic Hematopoietic Cell Transplantation (HCT).

Purpose of review: The outcome of allogeneic stem cell transplantation (allo-HCT) is still compromised by relapse and complications. NK cells and γδT cells, effectors which both function through MHC-unrestricted mechanisms, can target transformed and infected cells without inducing Graft-versus-Host Disease (GVHD). Allo-HCT platforms based on CD34+ selection or αβ-TCR depletion result in low grades of GVHD, early immune reconstitution (IR) of NK and γδT cells and minimal usage of GVHD prophylaxis. In this review we will discuss strategies to retain and expand the quantity, diversity and functionality of these reconstituting innate cell types.

Recent findings: Bisphosphonates, IL-15 cytokine administration, specific antibodies, checkpoint inhibitors and (CMV based) vaccination are currently being evaluated to enhance IR. All these approaches have shown to potentially enhance both NK and γδT cell immuno-repertoires.

Summary: Rapidly accumulating data linking innate biology to proposed clinical immune interventions, will give unique opportunities to unravel shared pathways which determine the Graft-versus-Tumor effects of NK and γδT cells.

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来源期刊
Current Stem Cell Reports
Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
0.00%
发文量
19
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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