衰老和kr佩尔样因素。

Trends in cell & molecular biology Pub Date : 2017-01-01
Paishiun N Hsieh, David R Sweet, Liyan Fan, Mukesh K Jain
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引用次数: 0

摘要

哺乳动物kr ppel样因子(KLFs)是一类含有锌指的转录因子家族,具有多种表达模式和广泛的细胞功能。虽然它们在哺乳动物生理学中的作用是众所周知的,但它们在调节衰老基本过程中的作用越来越受到重视。在这里,我们回顾了目前对kr ppel样因子的了解,重点关注它们在调节衰老和年龄相关疾病过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Aging and the Krüppel-like factors.

The mammalian Krüppel-like factors (KLFs) are a family of zinc-finger containing transcription factors with diverse patterns of expression and a wide array of cellular functions. While their roles in mammalian physiology are well known, there is a growing appreciation for their roles in modulating the fundamental progression of aging. Here we review the current knowledge of Krüppel-like factors with a focus on their roles in processes regulating aging and age-associated diseases.

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