Irena Cieċko-Michalska, Iga Wierzbicka-Tutka, Malgorzata Szczepanek, Danuta Fedak, Tomasz Mach
{"title":"细胞因子浓度是否可以作为IBD活性的标志，并可用于IBD分化的评估?］","authors":"Irena Cieċko-Michalska, Iga Wierzbicka-Tutka, Malgorzata Szczepanek, Danuta Fedak, Tomasz Mach","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In inflammatory bowel\ndisease (IBD) the imbalance between\ncytokines pro- and antinflammatory is\nobserved.\nThe aim of this study was the assessment\nof interleukin-10 (IL-10),\ninterleukin-6 (IL-6) and tumor necrosis\nfactor-α (TNF-α) concentration usefulness\nin the evaluation of the activity\nof ulcerative colitis (UC) and Cohn’s\ndisease (CD).</p><p><strong>Methods: </strong>35 patients diagnosed\nwith UC and 39 with CD were examined.\nThe control group (CG) consisted\nof 35 healthy volunteers. Diagnosis of\nthe disease was confirmed by videocolonoscopy\nand histopathological\nevaluation of intestinal biopsies.\nDisease activity of UC was assessed\naccording to the Mayo Scoring System\nand by the Crohn Disease Activiti Index\n(CDAI) in CD patients. Among patients\nwith UC 18 (51%) had severe, 14 (40%)\nmoderate and 3 (9%) mild disease.\nAmong patients with CD 7 (18%) was\ndiagnosed with high, 27 (69%) moderate,\nand 5 (13%) with low activity of\nthe disease. WBC, PLT, serum concentration\nof TNF-α, IL-6 i IL-10 were\ndetermined.</p><p><strong>Results: </strong>The average concentration\nof TNF-α in UC patients was: 14.3\n(IQR=12.6), in CD: 12.6 (IQR=11.9), in\nthe CG: 3.1 (IQR=1.7). The average\nconcentration of IL-6 in UC was: 19.6\n(IQR=21), in CD: 10.8 (IQR=7.6), in CG\n: 3.2 (IQR=1.6). The average concentration\nof IL-10 in UC was: 14.4 (IQR=5.9),\nin CD: 10.4 (IQR=9.3), in the CG: 3.3\n(IQR=2.5). In the IBD TNF-α, IL-6 and\nIL-10 concentration was significantly\nhigher than in CG. However, IL-10 was\nsignificantly higher in UC than CD. In\npatients with UC statistically significant\npositive correlation between the\nconcentration of TNF-α, IL-6 and IL-10\nand disease activity was noticed. There\nwere no correlation between TNF-α,\nIL-6 and IL-10 concentration and CD\nactivity.</p><p><strong>Conclusion: </strong>Determination of\nTNF-α, IL-6 and IL-10 serum concentration\ncan be used for noninvasive\nevaluation of inflammation activity in\npatients with IBD. IL-10 concentration\nmay be helpful in differentiation of UC and CD.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Could the cytokines concentration be a marker of IBD activity and be useful in evaluation of IBD differentiation?]\",\"authors\":\"Irena Cieċko-Michalska, Iga Wierzbicka-Tutka, Malgorzata Szczepanek, Danuta Fedak, Tomasz Mach\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In inflammatory bowel\\ndisease (IBD) the imbalance between\\ncytokines pro- and antinflammatory is\\nobserved.\\nThe aim of this study was the assessment\\nof interleukin-10 (IL-10),\\ninterleukin-6 (IL-6) and tumor necrosis\\nfactor-α (TNF-α) concentration usefulness\\nin the evaluation of the activity\\nof ulcerative colitis (UC) and Cohn’s\\ndisease (CD).</p><p><strong>Methods: </strong>35 patients diagnosed\\nwith UC and 39 with CD were examined.\\nThe control group (CG) consisted\\nof 35 healthy volunteers. Diagnosis of\\nthe disease was confirmed by videocolonoscopy\\nand histopathological\\nevaluation of intestinal biopsies.\\nDisease activity of UC was assessed\\naccording to the Mayo Scoring System\\nand by the Crohn Disease Activiti Index\\n(CDAI) in CD patients. Among patients\\nwith UC 18 (51%) had severe, 14 (40%)\\nmoderate and 3 (9%) mild disease.\\nAmong patients with CD 7 (18%) was\\ndiagnosed with high, 27 (69%) moderate,\\nand 5 (13%) with low activity of\\nthe disease. WBC, PLT, serum concentration\\nof TNF-α, IL-6 i IL-10 were\\ndetermined.</p><p><strong>Results: </strong>The average concentration\\nof TNF-α in UC patients was: 14.3\\n(IQR=12.6), in CD: 12.6 (IQR=11.9), in\\nthe CG: 3.1 (IQR=1.7). The average\\nconcentration of IL-6 in UC was: 19.6\\n(IQR=21), in CD: 10.8 (IQR=7.6), in CG\\n: 3.2 (IQR=1.6). The average concentration\\nof IL-10 in UC was: 14.4 (IQR=5.9),\\nin CD: 10.4 (IQR=9.3), in the CG: 3.3\\n(IQR=2.5). In the IBD TNF-α, IL-6 and\\nIL-10 concentration was significantly\\nhigher than in CG. However, IL-10 was\\nsignificantly higher in UC than CD. In\\npatients with UC statistically significant\\npositive correlation between the\\nconcentration of TNF-α, IL-6 and IL-10\\nand disease activity was noticed. There\\nwere no correlation between TNF-α,\\nIL-6 and IL-10 concentration and CD\\nactivity.</p><p><strong>Conclusion: </strong>Determination of\\nTNF-α, IL-6 and IL-10 serum concentration\\ncan be used for noninvasive\\nevaluation of inflammation activity in\\npatients with IBD. IL-10 concentration\\nmay be helpful in differentiation of UC and CD.</p>\",\"PeriodicalId\":21148,\"journal\":{\"name\":\"Przeglad lekarski\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przeglad lekarski\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Could the cytokines concentration be a marker of IBD activity and be useful in evaluation of IBD differentiation?]
Background: In inflammatory bowel
disease (IBD) the imbalance between
cytokines pro- and antinflammatory is
observed.
The aim of this study was the assessment
of interleukin-10 (IL-10),
interleukin-6 (IL-6) and tumor necrosis
factor-α (TNF-α) concentration usefulness
in the evaluation of the activity
of ulcerative colitis (UC) and Cohn’s
disease (CD).
Methods: 35 patients diagnosed
with UC and 39 with CD were examined.
The control group (CG) consisted
of 35 healthy volunteers. Diagnosis of
the disease was confirmed by videocolonoscopy
and histopathological
evaluation of intestinal biopsies.
Disease activity of UC was assessed
according to the Mayo Scoring System
and by the Crohn Disease Activiti Index
(CDAI) in CD patients. Among patients
with UC 18 (51%) had severe, 14 (40%)
moderate and 3 (9%) mild disease.
Among patients with CD 7 (18%) was
diagnosed with high, 27 (69%) moderate,
and 5 (13%) with low activity of
the disease. WBC, PLT, serum concentration
of TNF-α, IL-6 i IL-10 were
determined.
Results: The average concentration
of TNF-α in UC patients was: 14.3
(IQR=12.6), in CD: 12.6 (IQR=11.9), in
the CG: 3.1 (IQR=1.7). The average
concentration of IL-6 in UC was: 19.6
(IQR=21), in CD: 10.8 (IQR=7.6), in CG
: 3.2 (IQR=1.6). The average concentration
of IL-10 in UC was: 14.4 (IQR=5.9),
in CD: 10.4 (IQR=9.3), in the CG: 3.3
(IQR=2.5). In the IBD TNF-α, IL-6 and
IL-10 concentration was significantly
higher than in CG. However, IL-10 was
significantly higher in UC than CD. In
patients with UC statistically significant
positive correlation between the
concentration of TNF-α, IL-6 and IL-10
and disease activity was noticed. There
were no correlation between TNF-α,
IL-6 and IL-10 concentration and CD
activity.
Conclusion: Determination of
TNF-α, IL-6 and IL-10 serum concentration
can be used for noninvasive
evaluation of inflammation activity in
patients with IBD. IL-10 concentration
may be helpful in differentiation of UC and CD.
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