大kenchuto治疗便秘的疗效、安全性及临床疗效的剂量依赖性差异。

International Journal of Chronic Diseases Pub Date : 2018-03-05 eCollection Date: 2018-01-01 DOI:10.1155/2018/1296717
Tatsuya Hirose, Yasutaka Shinoda, Ayaka Kuroda, Aya Yoshida, Machiko Mitsuoka, Kouki Mori, Yuki Kawachi, Akihiro Moriya, Kouji Tanaka, Atsuko Takeda, Tomoaki Yoshimura, Tadashi Sugiyama
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引用次数: 2

摘要

背景:大kenchuto (DKT)是一种用于治疗便秘的汉布药。在这项研究中,我们评估了DKT治疗便秘的有效性。患者和方法:选择33例服用DKT治疗便秘的患者,分为低剂量组(7.5 g DKT;n = 22)和高剂量(15 g DKT;N = 11)组。我们回顾性地评估了每周排便次数、副作用和临床实验室数据。结果:33例患者服用DKT后的中位排便次数(第1、2、3、4周分别为5、5.5、5、8次)均显著高于服用DKT前的中位排便次数(2次)(P < 0.01)。水样便1例(3%),稀便1例(3%),无腹痛(0%)。高剂量组第1周(P = 0.0133)和第2周(P = 0.0101)排便次数中位数分别显著高于低剂量组(P = 0.0133)和低剂量组(P = 0.0101)。临床化验值无明显变化。结论:DKT能增加排便次数,治疗便秘是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects.

Background: Daikenchuto (DKT) is a Kampo medicine used for the treatment of constipation. In this study, we evaluated the effectiveness of DKT against constipation.

Patients and methods: Thirty-three patients administered DKT for constipation were selected and divided into low-dose (7.5 g DKT; n = 22) and high-dose (15 g DKT; n = 11) groups. We retrospectively evaluated weekly defaecation frequency, side effects, and clinical laboratory data.

Results: Median defaecation frequencies after DKT administration (5, 5.5, 5, and 8 for the first, second, third, and fourth weeks, resp.) were significantly higher than that before DKT administration (2) in all 33 cases (P < 0.01). One case (3%) of watery stool, one case of loose stools (3%), and no cases of abdominal pain (0%) were observed. Median defaecation frequencies in the high-dose group (7 and 9) were significantly higher than those in the low-dose group (4 and 3) in the first (P = 0.0133) and second (P = 0.0101) weeks, respectively. There was no significant change in clinical laboratory values.

Conclusion: We suggest that DKT increases defaecation frequency and is safe for treating constipation.

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审稿时长
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