Laura Giusti , Federica Ciregia , Alessandra Bonotti , Ylenia Da Valle , Elena Donadio , Claudia Boldrini , Rudy Foddis , Gino Giannaccini , Maria R. Mazzoni , Pier Aldo Canessa , Alfonso Cristaudo , Antonio Lucacchini
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Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM).
Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.
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