1型糖尿病的c肽替代治疗:我们是否处于幻灭的低谷?

IF 3.743 Q2 Biochemistry, Genetics and Molecular Biology Molecular BioSystems Pub Date : 2017-06-30 DOI:10.1039/C7MB00199A

C. W. Pinger, K. E. Entwistle, T. M. Bell, Y. Liu and D. M. Spence

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引用次数: 18

摘要

1型糖尿病与失明、肾衰竭和神经损伤等并发症有关。替代c肽，一种通常与胰岛素共同分泌的激素，已被证明可以减少糖尿病相关并发症。有趣的是，在近30年的积极研究成果之后，c肽仍然没有与胰岛素共同应用于糖尿病患者。下面的综述讨论了c肽作为辅助替代疗法的潜力，以及为什么它目前没有被用作治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, after nearly 30 years of positive research results, C-peptide is still not being co-administered with insulin to diabetic patients. The following review discusses the potential of C-peptide as an auxilliary replacement therapy and why it's not currently being used as a therapeutic.

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来源期刊

Molecular BioSystems 生物-生化与分子生物学

CiteScore

2.94

自引率

0.00%

发文量

审稿时长

2.6 months

期刊介绍： Molecular Omics publishes molecular level experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. We will also welcome multidisciplinary papers presenting studies combining different types of omics, or the interface of omics and other fields such as systems biology or chemical biology.