Alternathera mosaic potexvirus:几个特征、特性和应用。

IF 1.1 Q4 VIROLOGY Advances in Virology Pub Date : 2018-06-19 DOI:10.1155/2018/1973705
Ekaterina Donchenko, Ekaterina Trifonova, Nikolai Nikitin, Joseph Atabekov, Olga Karpova
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引用次数: 1

摘要

Alternathera mosaic virus(AltMV)在形态和基因组结构上是Potexvirus属的典型成员;尽管如此,它还是展现了许多独特的特点。它们使这种病毒被认为是生物技术的一个有前途的目标。AltMV的病毒和病毒样颗粒(VLP)在各种条件下都是稳定的,包括实验室动物的血清。AltMV VLP可以在各种pH和离子强度下组装。此外,AltMV病毒粒子和VLP表现出高免疫原性,增强了对靶抗原的免疫反应,从而提供了用作潜在佐剂的可能性。最近,对于植物病毒,我们首次显示了AltMV病毒粒子和VLP上形态相似的病毒和病毒样颗粒之间的结构差异。在这篇综述中,我们讨论了AltMV病毒粒子的特征、AltMV-VLP组装及其结构和性质,以及AltMV分离株的特征、宿主植物、感染症状、AltMV分离和纯化、基因组结构、病毒蛋白和基于AltMV的载体。
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Alternanthera mosaic potexvirus: Several Features, Properties, and Application.

Alternanthera mosaic virus (AltMV) is a typical member of the Potexvirus genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stable in a wide range of conditions, including sera of laboratory animals. AltMV VLPs can assemble at various pH and ionic strengths. Furthermore, AltMV virions and VLPs demonstrate high immunogenicity, enhancing the immune response to the target antigen thus offering the possibility of being used as potential adjuvants. Recently, for the first time for plant viruses, we showed the structural difference between morphologically similar viral and virus-like particles on AltMV virions and VLPs. In this review, we discuss the features of AltMV virions, AltMV VLP assembly, and their structure and properties, as well as the characteristics of AltMV isolates, host plants, infection symptoms, AltMV isolation and purification, genome structure, viral proteins, and AltMV-based vectors.

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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
23
审稿时长
22 weeks
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