精神分裂症患者的代谢综合征:加纳中部地带的一项跨部门比较研究。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2018-06-28 DOI:10.1155/2018/6542983
Angela Owusu-Ansah, Anto Berko Panyin, Christian Obirikorang, Christian Agyare, Emmanuel Acheampong, Simon Kwofie, Enoch Odame Anto, Emmanuella Nsenbah Batu
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引用次数: 9

摘要

这项研究确定了在加纳库马西Komfo Anokye教学医院(KATH)精神科精神分裂症患者中MetS的患病率。这项横断面比较研究招募了348名精神分裂症患者,包括236名接受抗精神病药物治疗的患者和112名新诊断的治疗幼稚患者。根据世界卫生组织(世界卫生组织)、国际糖尿病联合会(IDF)和国家胆固醇教育计划成人治疗小组III(NCEP ATP III)标准评估MetS患病率。根据NCEP ATP III、世界卫生组织和IDF标准,MetS的总体患病率分别为14.1%、20.4%和23.6%,而加纳普通人群中报告的发病率分别为7.8%、3.9%和2.2%。根据NCEP ATP III(17.8%对6.2%;p=0.0001)、世界卫生组织(26.2%对8.0%;p<0.0001),和IDF(30.3%对10.0%;p<0.0001)。无论使用何种标准,与典型抗精神病药物相比,非典型抗精神病药患者中MetS普遍存在(即NCEP ATP III为17.1%对11.1%;世界卫生组织为29.5%对25.9%;IDF为44.3%对18.5%)。使用逻辑回归模型,肥胖、空腹血糖升高、总胆固醇升高和高密度脂蛋白降低是MetS的显著预测因素(p
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Metabolic Syndrome among Schizophrenic Patients: A Comparative Cross-Sectional Study in the Middle Belt of Ghana.

The study determined the prevalence of MetS in patients with schizophrenia at the Psychiatric Unit of the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. This comparative cross-sectional study recruited 348 schizophrenic patients comprising 236 antipsychotic-treated and 112 newly diagnosed treatment-naïve patients. The MetS prevalence was assessed based on World Health Organization (WHO), International Diabetes Federation (IDF), and the National Cholesterol Education Programme, Adult Treatment Panel III (NCEP ATP III) criteria. The overall prevalence of MetS was 14.1%, 20.4%, and 23.6% using NCEP ATP III, WHO, and IDF criteria, respectively, compared to 7.8%, 3.9%, and 2.2% reported in the general Ghanaian population. The prevalence was significantly higher among treated psychiatric patients compared to treatment-naïve group based on NCEP ATP III (17.8% versus 6.2%; p = 0.0001), WHO (26.2% versus 8.0%; p < 0.0001), and IDF (30.3% versus 10.0%; p < 0.0001). MetS was prevalent among patients on atypical antipsychotics compared to typical antipsychotics irrespective of the criteria used (i.e., 17.1% versus 11.1% for NCEP ATP III; 29.5% versus 25.9% for WHO; and 44.3% versus 18.5% for IDF). Using logistic regression model, obesity, raised fasting blood sugar, raised total cholesterol, and decreased high density lipoprotein were observed to be significant predictors of MetS (p<0.05).The study found high prevalence of MetS in Ghanaians with schizophrenia and higher prevalence rate of MetS associated with monotherapy. Regular monitoring of cardiometabolic parameters should be an important therapeutic objective in the management of these patients.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
期刊最新文献
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