同型半胱氨酸可能调节类风湿关节炎的血管功能。

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2018-07-02 eCollection Date: 2018-01-01 DOI:10.1155/2018/8498651
Mahmoud A Alomari, Omar F Khabour, Khaldoon Alawneh, Rania A Shammaa
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引用次数: 4

摘要

同型半胱氨酸对心血管疾病的影响仍不明确,特别是在类风湿性关节炎患者中。在这项调查中,同型半胱氨酸与血流量和血管阻力在类风湿关节炎之间的关系进行了检查。采用ELISA法测定了31例类风湿关节炎患者和19例表面健康受试者的血清同型半胱氨酸水平。此外,应变计体积描记术用于测定静止和闭塞后前臂血流和血管功能。类风湿关节炎患者前臂闭塞血流(21.9±6.55 ml/100mL/min)低于对照组(25.5±6.10ml/100mL/min) (p < 0.05),闭塞血管阻力(4.77±2.08 ml/ min)高于对照组(3.05±0.96U) (p < 0.01)。类风湿关节炎组与健康组血清同型半胱氨酸水平相似(p = 0.803)。此外,血清同型半胱氨酸水平与静息血流量相关(r = -0.41;P < 0.02)和静息血管阻力(r = 0.31, P < 0.05)。该研究证实了类风湿关节炎患者血管功能的改变。独特的是,结果显示同型半胱氨酸与静息有关,而与缺血后血管测量无关。这些关系表明同型半胱氨酸可能影响类风湿关节炎的血管系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine.

The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Additionally, strain-gauge plethysmography was used to determine both forearm blood flow and vascular function at rest and after occlusion. Forearm occlusion blood flow (patients: 21.9 ± 6.55 versus control: 25.5 ± 6.10ml/100mL/min) was lower (p < 0.05) while occlusion vascular resistance (patients: 4.77 ± 2.08 versus controls 3.05 ± 0.96U) was greater (p < 0.01) in rheumatoid arthritis than in the controls. Level of serum homocysteine was similar (p = 0.803) in rheumatoid arthritis group and healthy group. In addition, level of serum homocysteine was correlated with resting blood flow (r = -0.41; p < 0.02) and resting vascular resistance (r = 0.31, p < 0.05) in the patients group. The study confirms altered vascular function in rheumatoid arthritis. Uniquely, the results show that homocysteine was related to resting, but not postischemia, vascular measures. These relationships indicate that homocysteine might impact the vasculature in rheumatoid arthritis.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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