局部配方的影响:角质层的脂质片层组织和脂质组成作为屏障完整性的替代标志物。

Current problems in dermatology Pub Date : 2018-01-01 Epub Date: 2018-08-21 DOI:10.1159/000489530
Dorothee Dähnhardt, Christian Surber, Stephan Dähnhardt-Pfeiffer
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引用次数: 7

摘要

皮肤屏障修复疗法通常涉及使用药物和非药物局部制剂。为了测量外用制剂的效果,临床(评分系统,例如特应性皮炎评分,皮肤病生活质量指数)和生物物理程序(例如经表皮水分流失,皮肤水合作用)被广泛使用。然而,这些程序的结果间接地描述了屏障的状况。对皮肤屏障完整性的直接评估主要是通过电子显微镜检查、角质层(SC)细胞间隙脂质片的可视化和形态计量学分析,以及对关键SC脂质组成的定量表征。最近,一种非侵入性脂质屏障可视化(Lipbarvis®)技术(SC取样和形态分析)和SC脂质成分分析(色谱分析)的结合被提出直接表征皮肤屏障的完整性。初步经验表明,SC细胞间隙脂质层组织的形态计量学分析以及关键SC脂质组成的表征可以作为研究局部非药物制剂(包括降ph制剂)影响的替代标记物。
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Influence of Topical Formulations: Lipid Lamella Organization and Lipid Composition of Stratum Corneum as a Surrogate Marker for Barrier Integrity.

Skin barrier repair therapies often involve the use of medicated and non-medicated topical preparations. To measure the effect of topical preparations, clinical (scoring systems, for example, Score of Atopic Dermatitis, Dermatology Quality of Life Index) and biophysical procedures (e.g., trans-epidermal water loss, skin hydration) are widely used. However, the results of these procedures describe the condition of the barrier indirectly. A direct assessment of skin barrier integrity is primarily possible by electron-microscopic examination, visualization and morphometric analysis of the lipid lamellae in the intercellular space of the stratum corneum (SC) and by quantitatively characterizing the composition of key SC lipids. Recently, the combination of a non-invasive lipid barrier visualization (Lipbarvis®) technique (SC sampling and morphometric analysis) and SC lipid composition analysis (chromatographic analysis) has been proposed to directly characterize the skin barrier integrity. Initial experience demonstrates that morphometric analysis of the lipid lamellae organization in the intercellular space of the SC as well as the characterization of the composition of key SC lipids may serve as surrogate marker to study the influence of topical non-medicated preparations including pH-lowered preparations.

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