烟酒醇提物细胞毒性的植物化学研究与评价。

International Journal of Medicinal Chemistry Pub Date : 2018-08-01 eCollection Date: 2018-01-01 DOI:10.1155/2018/8908435

Juan Carlos Romero-Benavides, Gina C Ortega-Torres, Javier Villacis, Sara L Vivanco-Jaramillo, Karla I Galarza-Urgilés, Natalia Bailon-Moscoso

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引用次数: 9

摘要

Baccharis属的一些物种已被证明具有重要的生物医学特性，包括细胞毒性活性。在这项研究中，我们检测了obtusifolia (Asteraceae)甲醇提取物对前列腺(PC-3)、结肠癌(RKO)、星形细胞瘤(D-384)和乳腺癌(MCF-7)细胞系的细胞毒性作用。甲醇提取物在结肠癌(RKO)和脑星形细胞瘤(D-384)细胞系中显示出最大的实质细胞毒作用。通过色谱纯化，分离鉴定出5,4′-二羟基-7-甲氧基黄酮(1)和5-羟基-7,4′-二甲氧基黄酮(2)类黄酮化合物。

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Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia.

Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extract displayed the largest substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral astrocytoma (D-384). Chromatographic purification of the B. obtusifolia methanolic extract led to the isolation and identification of 5,4'-dihydroxy-7-methoxyflavone (1) and 5-hydroxy-7,4'-dimethoxyflavone (2) compounds of the flavonoid type.

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International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.