EMICORON合成的新进展。

Q2 Biochemistry, Genetics and Molecular Biology High-Throughput Pub Date : 2018-08-29 DOI:10.3390/ht7030022

Massimo Pitorri, Marco Franceschin, Ilaria Serafini, Alessandro Ciccòla, Claudio Frezza, Armandodoriano Bianco

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引用次数: 1

摘要

本文报道了对获得EMICORON的常用方案中的两个合成步骤的修改。EMICORON是一种苯并[ghi]苝-二亚胺，于2012年在我们实验室首次合成，并已证明具有体内抗肿瘤活性，通过多靶点作用机制干扰肿瘤的生长发育。所提供的修改，包括反应时间、反应条件和后处理程序，使该工艺的总收率从28%提高到40%左右。因此，这种新方法可能更适合回收更多的EMICORON用于进一步的临床前研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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New Developments in the Synthesis of EMICORON.

This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies.

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来源期刊

High-Throughput Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： High-Throughput (formerly Microarrays, ISSN 2076-3905) is a multidisciplinary peer-reviewed scientific journal that provides an advanced forum for the publication of studies reporting high-dimensional approaches and developments in Life Sciences, Chemistry and related fields. Our aim is to encourage scientists to publish their experimental and theoretical results based on high-throughput techniques as well as computational and statistical tools for data analysis and interpretation. The full experimental or methodological details must be provided so that the results can be reproduced. There is no restriction on the length of the papers. High-Throughput invites submissions covering several topics, including, but not limited to: -Microarrays -DNA Sequencing -RNA Sequencing -Protein Identification and Quantification -Cell-based Approaches -Omics Technologies -Imaging -Bioinformatics -Computational Biology/Chemistry -Statistics -Integrative Omics -Drug Discovery and Development -Microfluidics -Lab-on-a-chip -Data Mining -Databases -Multiplex Assays