Hippo通路在心脏再生中的调控和功能。

Q1 Biochemistry, Genetics and Molecular Biology Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2019-01-01 Epub Date: 2018-08-31 DOI:10.1002/wdev.335
Shijie Liu, James F Martin
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引用次数: 21

摘要

由心肌细胞丧失和纤维化引起的心力衰竭是世界范围内死亡的主要原因。虽然目前治疗心力衰竭的方法如心脏移植和左心室辅助装置植入有明显的价值,但需要新的方法。内源性成人心肌细胞更新是可测量的,但在应对广泛的急性心脏损伤时效率低下和不足。刺激内源性心肌细胞的自我更新对心脏修复有很大的希望。揭示心肌细胞更新的遗传机制是开发修复心脏新方法的关键一步。最近的研究表明,抑制Hippo通路足以促进内源性心肌细胞的增殖,这表明在心脏中操纵Hippo通路可能是未来治疗心力衰竭的一种有希望的方法。我们总结了最近的研究结果,阐明了Hippo通路在心脏再生中的功能。我们还讨论了Hippo通路抑制促进心脏再生的机制,以及Hippo通路在再生过程中如何响应不同类型的损伤或应激。本文分类如下:成体干细胞,组织更新和再生>再生。
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The regulation and function of the Hippo pathway in heart regeneration.

Heart failure caused by cardiomyocyte loss and fibrosis is a leading cause of death worldwide. Although current treatments for heart failure such as heart transplantation and left ventricular assist device implantation have obvious value, new approaches are needed. Endogenous adult cardiomyocyte renewal is measurable but inefficient and inadequate in response to extensive acute heart damage. Stimulating self-renewal of endogenous cardiomyocytes holds great promise for heart repair. Uncovering the genetic mechanisms underlying cardiomyocyte renewal is a critical step in developing new approaches to repairing the heart. Recent studies have revealed that the inhibition of the Hippo pathway is sufficient to promote the proliferation of endogenous cardiomyocytes, indicating that the manipulation of the Hippo pathway in the heart may be a promising treatment for heart failure in the future. We summarize recent findings that have shed light on the function of the Hippo pathway in heart regeneration. We also discuss the mechanisms by which Hippo pathway inhibition promotes heart regeneration and how the Hippo pathway responds to different types of injury or stress during the regenerative process. This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration.

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期刊介绍: Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.
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