一个预测模型,以确定熟练护理机构居民药师干预。

Lauren J Heath, Thomas Delate, Linda Weffald, Dwight C Paulson, Julie K Sanchez, Sheri J Herner
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引用次数: 1

摘要

目的建立一个预测模型来识别在熟练护理机构(SNF)中需要临床药师干预的患者。设计回顾,横断面。在综合保健服务系统内设置9个独立的snf。在2016年1月1日至2017年4月30日期间接受临床药师用药审查的患者。确定的患者(n = 2594)被随机分配到推导和验证队列。干预措施采用多变量logistic回归模型来确定需要干预的患者的预测因素(即,药物剂量调整,开始或停止)。从管理数据库中收集患者特定因素(如人口统计学、药物分配、诊断)。在衍生队列中建立了基于临床判断和统计评估的简约模型,并对验证队列进行了拟合评估。主要结果测量模型预测需要临床药师干预的患者。次要结果是接受和未接受临床药师干预的患者之间的因素比较。结果共评估了95个因素。推导模型(n = 1,299)包含22个因子(曲线下面积[AUC] = 0.79, 95%置信区间[CI] 0.74-0.84)。在临床药师用药审查前180天内,氯吡格雷配药(比值比[OR] = 2.42, 95% CI 1.19-4.91)、跌倒(OR = 2.47, 95% CI 1.59-3.83)或椎体骨折诊断(OR = 2.33, 95% CI 1.34-4.05)可预测需要干预。该模型与验证队列(n = 1,295)拟合良好,AUC = 0.79 (95% CI 0.74-0.84)。结论管理数据预测SNF患者需要临床药师干预。该模型的实时应用可以节省临床药师的时间,并通过更直接的患者护理改善药房服务。
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A Predictive Model to Identify Skilled Nursing Facility Residents for Pharmacist Intervention.

Objective Develop a predictive model to identify patients in a skilled nursing facility (SNF) who require a clinical pharmacist intervention. Design Retrospective, cross-sectional. Setting Nine freestanding SNFs within an integrated health care delivery system. Patients Patients who received a clinical pharmacist medication review between January 1, 2016, and April 30, 2017. Identified patients (n = 2,594) were randomly assigned to derivation and validation cohorts. Interventions Multivariable logistic regression modeling was performed to identify factors predictive of patients who required an intervention (i.e., medication dose adjustment, initiation, or discontinuation). Patient-specific factors (e.g., demographics, medication dispensings, diagnoses) were collected from administrative databases. A parsimonious model based on clinical judgment and statistical assessment was developed in the derivation cohort and assessed for fit in the validation cohort. Main Outcome Measures Model to predict patients requiring clinical pharmacist intervention. Secondary outcome was a comparison of factors between patients who did and did not receive a clinical pharmacist intervention. Results Ninety-five factors were assessed. The derivation (n = 1,299) model comprised 22 factors (area under the curve [AUC] = 0.79, 95% confidence interval [CI] 0.74-0.84). A clopidogrel dispensing (odds ratio [OR] = 2.42, 95% CI 1.19-4.91), fall (OR = 2.47, 95% CI 1.59-3.83), or diagnosis for vertebral fracture (OR = 2.33, 95% CI 1.34-4.05) in the 180 days prior to clinical pharmacist medication review were predictive of requiring an intervention. The model fit the validation cohort (n = 1,295) well, AUC = 0.79 (95% CI 0.74-0.84). Conclusion Administrative data predicted patients in a SNF who required clinical pharmacist intervention. Application of this model in real-time could result in clinical pharmacist time-savings and improved pharmacy services through more directed patient care.

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来源期刊
CONSULTANT PHARMACIST
CONSULTANT PHARMACIST PHARMACOLOGY & PHARMACY-
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期刊介绍: Vision ... The Society"s long-term desire, aspiration, and core purpose. The vision of the American Society of Consultant Pharmacists is optimal medication management and improved health outcomes for all older persons. Mission ... The Society"s strategic position, focus, and reason for being. The American Society of Consultant Pharmacists empowers pharmacists to enhance quality of care for all older persons through the appropriate use of medication and the promotion of healthy aging.
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