评估作为银屑病患者疾病严重程度潜在标志的 ADA 活性。

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2018-09-04 eCollection Date: 2018-01-01 DOI:10.2147/PTT.S174119
Seraj Ahmed Khan, Sudha Agrawal, Nirmal Baral, Madhab Lamsal
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引用次数: 0

摘要

背景:目的:本研究旨在探讨血清 ADA 活性、尿酸(UA)和高敏 CRP(hs-CRP)与银屑病的关系,以及 ADA 在疾病严重程度中的作用:在这项横断面比较研究中,共纳入了 50 名经临床和组织病理学诊断的银屑病患者和 50 名年龄和性别匹配的健康对照者。采集血液样本,并根据 Giuisti 和 Galanti 法、尿酸酶和 ELISA 技术分别对 ADA 活性、UA 和 hs-CRP 进行生化指标分析。疾病的严重程度根据银屑病面积和严重程度指数(PASI)进行评分。采用学生 t 检验、单因素方差分析和皮尔逊相关分析对研究组内和研究组间的差异进行统计分析。线性回归用于确定 ADA 与疾病严重程度的独立关联:结果:发现银屑病患者的血清 ADA 活性、UA 和 hs-CRP 水平显著较高(PPP 结论:ADA 活性与银屑病严重程度呈显著正相关:ADA活性与银屑病的严重程度呈显著正相关,因此可作为银屑病患者疾病严重程度的标志物。
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Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients.

Background: Psoriasis is a dermatological disorder with a multifactorial origin and is associated with many biochemical and immunological changes.

Purpose: This study aimed to examine the association of serum ADA activity, uric acid (UA), and high-sensitivity CRP (hs-CRP) with psoriasis and the role of ADA in disease severity.

Materials and methods: In this comparative cross-sectional study, 50 clinically and histopathologically diagnosed psoriasis patients and 50 age- and sex-matched healthy controls were enrolled. Blood samples were taken and analysis of the biochemical parameters was performed according to Giuisti and Galanti method, uricase and ELISA technique for ADA activity, UA, and hs-CRP, respectively. The severity of the disease was scored according to Psoriasis Area and Severity Index (PASI). Statistical analysis of differences within and between the study groups was carried out using the Student's t-test, one-way post hoc ANOVA, and Pearson's correlation. Linear regression was used to establish the independent association of ADA with disease severity.

Results: The serum ADA activity, UA, and hs-CRP levels of the psoriatic patients were found to be significantly higher (P<0.001). hs-CRP was positively correlated with ADA and UA in patients (P<0.001). There was no significant difference in total cholesterol, low-density lipoprotein, and triacylglycerol in psoriasis patients, whereas we noted a decreased high-density lipoprotein level in psoriasis patients as compared to controls. Linear regression showed that ADA was independently associated with the disease severity and was statistically significant (P<0.001).

Conclusion: ADA activity was positively and significantly associated with the severity of psoriasis, therefore, it could be suggested as a marker for disease severity in psoriasis patients.

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