S100蛋白在自身炎症性疾病发病机制和监测中的作用。

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2018-09-25 DOI:10.1186/s40348-018-0085-2
Dirk Holzinger, Dirk Foell, Christoph Kessel
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引用次数: 36

摘要

S100A8/A9和S100A12从活化的单核细胞和粒细胞中释放,作为促炎内源性toll样受体(TLR)4配体。在局部和全身炎症过程中,血清S100浓度与疾病活动性相关。在一些自身炎症性疾病,如家族性地中海热(FMF)或系统性青少年特发性关节炎(SJIA)中,S100释放的失调可能参与了发病机制。此外,血清S100水平是诊断不明原因发热中SJIA的宝贵支持工具。此外,S100水平可用于监测疾病活动至亚临床水平,因为其血清浓度随着治疗成功而降低。
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The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases.

S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic inflammatory processes. In some autoinflammatory diseases such as familial Mediterranean fever (FMF) or systemic juvenile idiopathic arthritis (SJIA), dysregulation of S100 release may be involved in the pathogenesis. Moreover, S100 serum levels are a valuable supportive tool in the diagnosis of SJIA in fever of unknown origin. Furthermore, S100 levels can be used to monitor disease activity to subclinical level, as their serum concentrations decrease with successful treatment.

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