Gustavo Dias Ferreira, José Augusto Simões, Chamara Senaratna, Sanghamitra Pati, Pierre Fernando Timm, Sandro Rodrigues Batista, Bruno Pereira Nunes
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引用次数: 12
摘要
背景:多病是指同一个体同时出现两种或两种以上的疾病。在早期阶段识别这种疾病的一种方法是使用各种发病率组合的特定标记物。然而，与多重发病的生理标志物相关的证据是有限的。目的:目的是进行系统评价，以确定与多病相关的生理标志物。设计:系统地检索和回顾了PubMed、Register of Controlled Trials、Academic Search Premier、CINAHL、Scopus、SocINDEX、Web of Science、LILACS和SciELO上从创立到2018年5月的文章。该项目在普洛斯彼罗注册，编号为CRD42017055522。结果:系统检索到922篇论文。经过评估，18篇文章被纳入完整综述，报告了共存疾病中至少一种生理标志物或与未来多病的存在密切相关。这些研究中只有五项研究一般地检查了多病，确定了五种与多病相关的生理标志物，即脱氢表雄酮硫酸酯(DHEAS)、白细胞介素6 (IL-6)、C反应蛋白(CRP)、脂蛋白(Lp)和胱抑素C (Cyst-C)。结论:目前缺乏与多发病生理标志物相关的研究。DHEAS、IL-6、CRP、Lp和Cyst-C可能是进一步研究多发病相关生理标志物的初步重点。
Physiological markers and multimorbidity: A systematic review.
Background: Multimorbidity is the co-occurrence of two or more diseases in the same individual. One method to identify this condition at an early stage is the use of specific markers for various combinations of morbidities. Nonetheless, evidence related to physiological markers in multimorbidity is limited.
Objective: The aim was to perform a systematic review to identify physiological markers associated with multimorbidity.
Design: Articles available on PubMed, Register of Controlled Trials, Academic Search Premier, CINAHL, Scopus, SocINDEX, Web of Science, LILACS, and SciELO, from their inception to May 2018, were systematically searched and reviewed. The project was registered in PROSPERO under the number CRD42017055522.
Results: The systematic search identified 922 papers. After evaluation, 18 articles were included in the full review reporting at least one physiological marker in coexisting diseases or which are strongly associated with the presence of multimorbidity in the future. Only five of these studies examined multimorbidity in general, identifying five physiological markers associated with multimorbidity, namely, dehydroepiandrosterone sulfate (DHEAS), interleukin 6 (IL-6), C-reactive protein (CRP), lipoprotein (Lp), and cystatin C (Cyst-C).
Conclusions: There is a paucity of studies related to physiological markers in multimorbidity. DHEAS, IL-6, CRP, Lp, and Cyst-C could be the initial focus for further investigation of physiological markers related to multimorbidity.
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