Garcinol富集部位对佐剂性关节炎的抗关节炎作用。

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics Recent patents on inflammation & allergy drug discovery Pub Date : 2019-01-01 DOI:10.2174/1872213X12666181120091528
Purnima Warriar, Kalyani Barve, Bala Prabhakar
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引用次数: 13

摘要

背景:藤黄在传统医学系统中用于缓解炎症和风湿痛。Garcinol是一种从其果皮中提取的二苯甲酮,据报道通过调节花生四烯酸代谢、抑制iNOS表达、NF-κB活化和COX-2表达而具有抗炎作用。还研究了它的抗氧化和抗癌活性。除此之外,很少有专利声称garcinol还具有抗肥胖和保护肝脏的作用,并有可能用于治疗肾脏疾病、子宫内膜异位症和心功能障碍。目的:前期实验表明,从黄藤果皮提取的Garcinol富集部位(GEF)具有抗炎作用,可有效治疗慢性炎症性疾病之一的关节炎。方法:以藤黄果皮为原料制备GEF,采用LC-MS/MS进行定量分析。结果发现,它含有89.4% w/w的garcinol。以10mg/kg剂量评价GEF对Wistar白化大鼠完全弗氏佐剂(CFA)诱导的关节炎的疗效。分别于第0、1、5、12、21天用体积计测量双侧爪体积,并记录体重。用运动试验和爬楼梯试验测定痛觉过敏反应。结果:GEF显著降低足跖肿胀(p < 0.0001)和关节炎指数(p < 0.0001),具有抗炎作用。提高了实验动物的运动能力和爬楼梯能力(p < 0.05),减轻了痛觉过敏。结论:Garcinol富集部位对实验动物具有抗关节炎作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis.

Background: Garcinia indica also known as kokum is used in traditional system of medicine for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant and anticancer activity. Apart from these, few patents claim that garcinol also has anti-obesity and hepatoprotective effect and has a potential to be used for the treatment of renal disorders, endometriosis and cardiac dysfunction.

Objective: Garcinol Enriched Fraction (GEF) from the fruit rind of Garcinia indica should be effective in the treatment of arthritis, one of the chronic inflammatory disorder owing to its anti-inflammatory property as indicated by earlier experiments.

Methods: GEF was prepared from the fruit rind of Garcinia indica and quantified using LC-MS/MS. It was found to contain 89.4% w/w of garcinol. GEF was evaluated at the dose of 10mg/kg for its efficacy against Complete Freund's Adjuvant (CFA) induced arthritis in Wistar albino rats. Paw volumes of both sides were measured by Plethysmometer and body weight was recorded on 0, 1, 5, 12 and 21st day. The hyperalgesic response was also measured by motility test and stair climbing test.

Results: GEF showed a significant reduction in paw swelling (p < 0.0001) and arthritis index (p < 0.0001) exhibiting anti-inflammatory potential. It also improves the motility and stair climbing ability of experimental animals (p < 0.05), thus reducing hyperalgesia.

Conclusion: Garcinol enriched fraction shows anti-arthritic activity in experimental animals.

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期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
期刊最新文献
Meet Our Editorial Board Member Diagnosis of Allergic Reactions to Drugs Non-steroidal Anti-inflammatory Drugs Other Antimicrobial Drugs Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones
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