Ouldouz Ghashghaei , Carme Masdeu , Concepción Alonso , Francisco Palacios , Rodolfo Lavilla
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Recent advances of the Povarov reaction in medicinal chemistry
The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.
期刊介绍：
Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.
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