磷酸粘合剂在ESRD患者中的应用。

Nephrology news & issues Pub Date : 2016-08-01
Timothy Nguyen, Trung Pham, Tommy Huynh
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引用次数: 0

摘要

慢性肾脏疾病是一种复杂的疾病,其常见并发症之一与高磷血症有关。这可导致严重甲状旁腺功能亢进、软组织钙化、肺钙化、发病率和死亡率的发展。治疗高磷血症的主流疗法之一是磷酸盐结合剂药物(PBMs)。我们对150名服用药物治疗的ESRD患者进行了回顾性数据分析。患者被分为非钙基(如司维拉默)、钙基(如醋酸钙)或两者兼而有之,或未接受任何PBMs的患者。我们发现Sevelamer是最常用的PBM(53%),其次是醋酸钙(40%)。一些患者接受联合治疗。
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Phosphate binder choices used in ESRD patients.

Chronic kidney disease is a complex disease, and one of its common complications is associated with hyperphosphatemia. This can lead to the development of severe hyperparathyroidism, soft tissue calcification, calcification of the lung, morbidity, and mortality. One of the mainstream therapies for managing hyperphosphatemia are phosphate binder medications (PBMs). We did a retrospective data analysis of 150 ESRD patients who were taking PBMs. Patients were grouped into non-calcium based (e.g., sevelamer), calcium-based (e.g., calcium acetate), or both, or those patients that did not receive any PBMs. We found that Sevelamer was the most commonly used PBM (53%), and calcium acetate was the second most commonly used PBM (40%). Some patients received combination therapy.

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