行为表型在酒后驾驶再犯风险中的作用及其对短期干预的治疗反应的初步研究。

IF 3.2 3区 医学 Q1 Medicine Alcoholism, clinical and experimental research Pub Date : 2019-02-01 Epub Date: 2018-12-31 DOI:10.1111/acer.13935
Nathaniel Moxley-Kelly, Marie Claude Ouimet, Maurice Dongier, Florence Chanut, Jacques Tremblay, Walter Marcantoni, Thomas G Brown
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引用次数: 2

摘要

背景:酒后驾驶(DWI)罪犯群体的异质性和补救方案的适度结果激发了人们对明确临床上重要的DWI亚型的兴趣,以更好地评估再犯风险和目标干预。我们之前的研究确定了两种假定的酒后驾车罪犯的行为表型,它们具有不同的行为、个性、认知和神经生物学特征:(i)主要从事酒后驾车的罪犯(pDWI);(ii)从事酒后驾驶和其他交通违规的违规者(混合)。在这里,我们评估这些表型在预测再犯和干预目标方面的临床意义。方法:回顾性分析184名DWI累犯,将其分为pDWI组(N = 97)和MIXED组(N = 87)。随后,二级分析评估了这种表型分类对自我报告的6个月和12个月酒精滥用结果和记录的5年DWI累犯违规行为的影响,以及对BMI或IA的反应(即pDWI-BMI, n = 46;混合bmi, n = 45;pDWI-IA, n = 51;混合ia, n = 42)。测试了两个假设:(i)与pDWI分类相比,MIXED分类与较差的酒精滥用结果和再犯结果相关;(ii)与BMI配对的pDWI相比,与BMI配对的MIXED具有更好的预后。结果:在5年随访中,与pDWI分类相比,MIXED分类与更大的再犯风险相关。此外,与混合- bmi配对相比,pDWI-BMI配对与再犯风险显著降低相关。对6个月和12个月酒精使用结果的分析没有发现任何结果。结论:表型分类对再犯风险评估和针对性干预的临床意义得到部分支持。这和其他行为表型的前瞻性调查表明。
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The Role of Behavioral Phenotypes on Impaired Driving Recidivism Risk and Treatment Response to Brief Intervention: A Preliminary Study.

Background: Heterogeneity in the driving while impaired (DWI) offender population and modest outcomes from remedial programs are fueling interest in clarifying clinically significant DWI subtypes to better assess recidivism risk and target interventions. Our previous research identified 2 putative behavior phenotypes of DWI offenders with distinct behavioral, personality, cognitive, and neurobiological profiles: (i) offenders primarily engaging in DWI (pDWI); and (ii) offenders engaging in DWI and other traffic violations (MIXED). Here, we evaluate these phenotypes' clinical significance for prediction of recidivism and intervention targeting.

Methods: DWI recidivists participating in a previous randomized controlled trial (N = 184 comparing brief motivational interviewing (BMI) and an information and advice control condition (IA) were retrospectively classified as either pDWI (n = 97) or MIXED (n = 87). Secondary analyses then evaluated the effect of this phenotypic classification on self-reported 6- and 12-month alcohol misuse outcomes and documented 5-year DWI recidivism violations, and in response to either BMI or IA (i.e., pDWI-BMI, n = 46; MIXED-BMI, n = 45; pDWI-IA, n = 51; MIXED-IA, n = 42). Two hypotheses were tested: (i) MIXED classification is associated with poorer alcohol misuse outcomes and recidivism outcomes than pDWI classification; and (ii) pDWI paired with BMI is associated with better outcomes compared to MIXED paired with BMI.

Results: MIXED classification was associated with significantly greater risk of recidivism over the 5-year follow-up compared to pDWI classification. Moreover, the pDWI-BMI pairing was associated with significantly decreased recidivism risk compared to the MIXED-BMI pairing. Analyses of 6- and 12-month alcohol use outcomes produced null findings.

Conclusions: The clinical significance of phenotypic classification for risk assessment and targeting intervention was partially supported with respect to recidivism risk. Prospective investigation of this and other behavioral phenotypes is indicated.

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来源期刊
CiteScore
5.90
自引率
9.40%
发文量
219
审稿时长
1 months
期刊介绍: Alcoholism: Clinical and Experimental Research''s scope spans animal and human clinical research, epidemiological, experimental, policy, and historical research relating to any aspect of alcohol abuse, dependence, or alcoholism. This journal uses a multi-disciplinary approach in its scope of alcoholism, its causes, clinical and animal effect, consequences, patterns, treatments and recovery, predictors and prevention.
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