{"title":"辩论:儿科T1DM: DKA仍然是一个问题。","authors":"Elena Martínez, Nancy Portillo, Eneritz Lizarralde, Gema Grau, Amaia Vela, Amaia Rodríguez, Itxaso Rica","doi":"10.17458/per.vol16.2018.mpr.fd.t1dmdka","DOIUrl":null,"url":null,"abstract":"<p><p>Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.</p><p><strong>Objective: </strong>To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.</p><p><strong>Methods: </strong>Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Clinical/analytical variables at diabetes onset, Hemoglobin A1c level during the first 2 years of evolution and the presence of the honeymoon phase were studied.</p><p><strong>Results: </strong>In 209 patients the prevalence of DKA was stable over time and high (35.4%) especially in the youngest. 8.5% of patients had a severe DKA with a higher risk in older than 10. Partial remission occurred in 26% patients, less frequent in the youngest and in the subgroup with DKA at diagnosis.</p><p><strong>Conclusion: </strong>The frequency of DKA although stable, remains high and is associated with a worse evolution of the disease.</p>","PeriodicalId":19827,"journal":{"name":"Pediatric endocrinology reviews : PER","volume":"16 2","pages":"233-239"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"For Debate: Paediatric T1DM: DKA is Still a Problem.\",\"authors\":\"Elena Martínez, Nancy Portillo, Eneritz Lizarralde, Gema Grau, Amaia Vela, Amaia Rodríguez, Itxaso Rica\",\"doi\":\"10.17458/per.vol16.2018.mpr.fd.t1dmdka\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.</p><p><strong>Objective: </strong>To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.</p><p><strong>Methods: </strong>Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Clinical/analytical variables at diabetes onset, Hemoglobin A1c level during the first 2 years of evolution and the presence of the honeymoon phase were studied.</p><p><strong>Results: </strong>In 209 patients the prevalence of DKA was stable over time and high (35.4%) especially in the youngest. 8.5% of patients had a severe DKA with a higher risk in older than 10. Partial remission occurred in 26% patients, less frequent in the youngest and in the subgroup with DKA at diagnosis.</p><p><strong>Conclusion: </strong>The frequency of DKA although stable, remains high and is associated with a worse evolution of the disease.</p>\",\"PeriodicalId\":19827,\"journal\":{\"name\":\"Pediatric endocrinology reviews : PER\",\"volume\":\"16 2\",\"pages\":\"233-239\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric endocrinology reviews : PER\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.17458/per.vol16.2018.mpr.fd.t1dmdka\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric endocrinology reviews : PER","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.17458/per.vol16.2018.mpr.fd.t1dmdka","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
For Debate: Paediatric T1DM: DKA is Still a Problem.
Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.
Objective: To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.
Methods: Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Clinical/analytical variables at diabetes onset, Hemoglobin A1c level during the first 2 years of evolution and the presence of the honeymoon phase were studied.
Results: In 209 patients the prevalence of DKA was stable over time and high (35.4%) especially in the youngest. 8.5% of patients had a severe DKA with a higher risk in older than 10. Partial remission occurred in 26% patients, less frequent in the youngest and in the subgroup with DKA at diagnosis.
Conclusion: The frequency of DKA although stable, remains high and is associated with a worse evolution of the disease.
期刊介绍：
PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training.
PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.
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