利用光学相干断层扫描研究奥林匹克拳击手头部创伤可能的视网膜生物标志物。

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2018-12-14 eCollection Date: 2018-01-01 DOI:10.2147/EB.S183042
Charmaine Childs, Lynne A Barker, Alex Md Gage, Mike Loosemore
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引用次数: 13

摘要

目的:视网膜的改变在许多神经退行性疾病后已被报道。这项研究的目的是调查经常受到头部打击的奥运拳击手的视网膜结构。方法:视网膜成像为神经病理学的非侵入性生物标志物提供了潜力。使用光学相干断层扫描(OCT)测量了参加两次强制性眼科筛查项目的英国奥运拳击手的黄斑和视网膜神经纤维层(RNFL)厚度,间隔18个月。两次眼睛筛查的数据提供了视网膜随时间变化的纵向数据。在第二次拳击手筛查时,也对没有过去或现在脑震荡史的久坐健康受试者(对照组)进行筛查,以提供横截面数据的比较。结果:招募了16名年龄在20-33岁的奥运会拳击手和20名年龄在24-45岁的久坐健康对照者。随着时间的推移(18个月),75%的右眼和50%的左眼可见明显的黄斑增厚。对于RNFL,左眼象限变厚。右眼RNFL象限观察到该层增厚和变薄。横断面结果显示,与对照组相比,奥运会拳击手的黄斑区和RNFL象限更薄。结论:在健康的优秀运动员中,黄斑和RNFL密度在18个月的间隔内发生显著变化是出乎意料的。此外,黄斑和RNFL比健康久坐的对照组更薄。OCT作为轻度创伤性脑损伤和/或重复头部撞击后神经病理变化的候选视网膜生物标志物在临床上可能是有用的。
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Investigating possible retinal biomarkers of head trauma in Olympic boxers using optical coherence tomography.

Purpose: Changes to retina have been reported after a number of neurodegenerative conditions. The purpose of this study was to investigate retinal structures in Olympic boxers exposed to frequent head blows.

Methods: Retinal imaging offers potential as a non-invasive biomarker of neuropathology. Macula and retinal nerve fiber layer (RNFL) thickness was measured using optical coherence tomography (OCT) in UK Olympic boxers attending two mandatory eye screening programs, 18 months apart. Data from the two eye screenings provide longitudinal data of retinal change over time. Sedentary healthy subjects (controls) without past or present history of concussion were also screened at the time of the second boxer screening to provide comparison of cross-sectional data.

Results: Sixteen Olympic boxers aged 20-33 years and 20 sedentary healthy controls, aged 24-45 years, were recruited. Significant macula thickening was observed over time (18 months) in 75% of right and 50% of left eye sectors. For RNFL, left eye quadrants thickened. For right eye RNFL quadrants, thickening and thinning of this layer were observed. Cross-sectional results showed thinner macula sectors and RNFL quadrants in Olympic boxers compared to controls.

Conclusion: Significant change to macula and RNFL densities, occurring over an 18 month interval is an unexpected finding in otherwise heathy elite sportsmen. In addition, macula and RNFL were thinner than healthy sedentary controls. OCT may prove clinically useful as a candidate retinal biomarker of neuropathological change after mild traumatic brain injury and/or repeat head blows.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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