揭示查尔酮化学对单胺氧化酶抑制的结构要求。

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2019-01-01 DOI:10.2174/1871524919666190131160122

Bijo Mathew

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Unraveling the Structural Requirements of Chalcone Chemistry Towards Monoamine Oxidase Inhibition.

Due to the structural versatile, chalcones are considered as multi-targeted scaffold for the variety of enzyme targets. The present perspective focused our attention onto the monoamine oxidase inhibitory activity of synthetic chalcones which is synthesized in our lab recently. The studies clearly demonstrated that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A depending upon the substituents bearing around α-β-unsaturated linker of the chalcone scaffold.

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

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期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.