Vlado Perkovic , Jonathan C. Craig , Worawon Chailimpamontree , Caroline S. Fox , Guillermo Garcia-Garcia , Mohammed Benghanem Gharbi , Meg J. Jardine , Ikechi G. Okpechi , Neesh Pannu , Benedicte Stengel , Katherine R. Tuttle , Katrin Uhlig , Andrew S. Levey
{"title":"优化慢性肾脏疾病临床试验设计的行动计划","authors":"Vlado Perkovic , Jonathan C. Craig , Worawon Chailimpamontree , Caroline S. Fox , Guillermo Garcia-Garcia , Mohammed Benghanem Gharbi , Meg J. Jardine , Ikechi G. Okpechi , Neesh Pannu , Benedicte Stengel , Katherine R. Tuttle , Katrin Uhlig , Andrew S. Levey","doi":"10.1016/j.kisu.2017.07.009","DOIUrl":null,"url":null,"abstract":"<div><p>High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.</p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"7 2","pages":"Pages 138-144"},"PeriodicalIF":19.3000,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2017.07.009","citationCount":"18","resultStr":"{\"title\":\"Action plan for optimizing the design of clinical trials in chronic kidney disease\",\"authors\":\"Vlado Perkovic , Jonathan C. Craig , Worawon Chailimpamontree , Caroline S. Fox , Guillermo Garcia-Garcia , Mohammed Benghanem Gharbi , Meg J. Jardine , Ikechi G. Okpechi , Neesh Pannu , Benedicte Stengel , Katherine R. Tuttle , Katrin Uhlig , Andrew S. Levey\",\"doi\":\"10.1016/j.kisu.2017.07.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.</p></div>\",\"PeriodicalId\":48895,\"journal\":{\"name\":\"Kidney International Supplements\",\"volume\":\"7 2\",\"pages\":\"Pages 138-144\"},\"PeriodicalIF\":19.3000,\"publicationDate\":\"2017-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.kisu.2017.07.009\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kidney International Supplements\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2157171617300357\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney International Supplements","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2157171617300357","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Action plan for optimizing the design of clinical trials in chronic kidney disease
High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.
期刊介绍：
Kidney International Supplements is published on behalf of the International Society of Nephrology (ISN) and comes complimentary as part of a subscription to Kidney International. Kidney International Supplements is a peer-reviewed journal whose focus is sponsored, topical content of interest to the nephrology community.
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