移植后淋巴细胞增生性疾病的肿瘤微环境。

Q2 Medicine Cancer Microenvironment Pub Date : 2019-04-01 Epub Date: 2019-01-24 DOI:10.1007/s12307-018-00219-5
Lukas Marcelis, Thomas Tousseyn
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引用次数: 17

摘要

移植后淋巴细胞增生性疾病(ptld)涵盖实体器官或异体造血干细胞移植后引起的广泛淋巴细胞增生性病变。肿瘤微环境(tumor microenvironment, TME)由肿瘤的所有非恶性成分组成,其组成和功能在PTLD中受到4个因素的复杂相互作用的极大影响:1)移植器官通过慢性抗原呈递引起免疫刺激;2)防止器官排斥的治疗干扰免疫系统;3)致瘤性eb病毒(EBV)存在于80%的PTLDs中,在淋巴细胞的致瘤转化中起致病作用并影响免疫反应;4)与伴随移植物的供体来源的免疫细胞相互作用。这些因素使PTLDs成为研究癌症-微环境相互作用的有趣模型,目前的研究结果可能对包括实体肿瘤在内的其他恶性肿瘤也有意义。在这里,我们将回顾目前关于PTLD中TME组成的知识,重点关注PTLD开发中涉及的不同因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders.

Post-transplant lymphoproliferative disorders (PTLDs) cover a broad spectrum of lymphoproliferative lesions arising after solid organ or allogeneic hematopoietic stem cell transplantation. The composition and function of the tumor microenvironment (TME), consisting of all non-malignant constituents of a tumor, is greatly impacted in PTLD through a complex interplay between 4 factors: 1) the graft organ causes immune stimulation through chronic antigen presentation; 2) the therapy to prevent organ rejection interferes with the immune system; 3) the oncogenic Epstein-Barr virus (EBV), present in 80% of PTLDs, has a causative role in the oncogenic transformation of lymphocytes and influences immune responses; 4) interaction with the donor-derived immune cells accompanying the graft. These factors make PTLDs an interesting model to look at cancer-microenvironment interactions and current findings can be of interest for other malignancies including solid tumors. Here we will review the current knowledge of the TME composition in PTLD with a focus on the different factors involved in PTLD development.

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来源期刊
Cancer Microenvironment
Cancer Microenvironment Medicine-Oncology
CiteScore
4.90
自引率
0.00%
发文量
0
期刊介绍: Cancer Microenvironment is the official journal of the International Cancer Microenvironment Society (ICMS). It publishes original studies in all aspects of basic, clinical and translational research devoted to the study of cancer microenvironment. It also features reports on clinical trials. Coverage in Cancer Microenvironment includes: regulation of gene expression in the cancer microenvironment; innate and adaptive immunity in the cancer microenvironment, inflammation and cancer; tumor-associated stroma and extracellular matrix, tumor-endothelium interactions (angiogenesis, extravasation), cancer stem cells, the metastatic niche, targeting the tumor microenvironment: preclinical and clinical trials.
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