药物及幽门螺杆菌对系统性红斑狼疮及抗磷脂综合征患者胃黏膜变化的影响。

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2019-05-05 eCollection Date: 2019-01-01 DOI:10.1155/2019/9698086
Tatiana M Reshetnyak, Irina A Doroshkevich, Natalia V Seredavkina, Evgeny L Nasonov, Igor V Maev, Vasiliy I Reshetnyak
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引用次数: 7

摘要

背景:系统性红斑狼疮(SLE)和抗磷脂综合征(APS)患者胃粘膜(GM)损伤的性质和发生率仍是尚未解决的问题之一。目的:探讨幽门螺杆菌和药物在SLE和APS患者GM损伤发展中的作用。方法:对85例SLE合并APS患者进行研究。所有患者均行食管胃十二指肠镜检查,并对胃体和胃窦粘膜进行有针对性的活检。采用聚合酶链反应测定胃活检标本中幽门螺杆菌的存在。结果:内镜检查显示,SLE合并APS患者入院时GM变化为:胃窦性胃炎(82.4%)、糜烂(24.7%)、出血(8.2%)、胃脘炎(8.2%)。SLE和APS患者发现的GM损伤与幽门螺杆菌的存在没有直接关系。SLE和APS患者使用糖皮质激素、低剂量乙酰水杨酸、非甾体类抗炎药和抗凝血药时伴有GM损伤。结论:没有证据表明幽门螺杆菌在SLE和APS患者GM损伤中的作用。抗凝血剂或低剂量乙酰水杨酸使用者幽门螺杆菌检出率高于糖皮质激素和非甾体抗炎药使用者。
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The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome.

Background: The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems.

Objective: To define the role of H. pylori and drugs in the development of GM damages in SLE and APS.

Methods: A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction.

Results: Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage.

Conclusion: There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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