Maria Teresa Viggiani, Alfredo Di Leo, Michele Barone
{"title":"抗分泌因子可以作为短肠综合征的新疗法吗?","authors":"Maria Teresa Viggiani, Alfredo Di Leo, Michele Barone","doi":"10.1177/1178638819852061","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>The antisecretory factor (AF) exerts antisecretory and anti-inflammatory properties in the bowel. The aim of this study was to evaluate the effect of exogenous AF (Salovum) or cereals stimulating the endogenous AF (SPC-Flakes), given alone or in combination, in patients with short bowel syndrome (SBS).</p><p><strong>Methods: </strong>Patients received Salovum alone at T<sub>0</sub> -T<sub>1</sub>, Salovum plus SPC-Flakes at T<sub>1</sub> -T<sub>2</sub>, and SPC-Flakes alone at T<sub>2</sub> -T<sub>3</sub>. At T<sub>0</sub> and T<sub>3</sub>, water balance, weight, lean mass (FFM), total body water (TBW), extracellular water (ECW), and nutritional and inflammatory biochemical parameters were evaluated. The water balance was also measured at T<sub>1</sub>, T<sub>2</sub>, and 30 days (T<sub>S</sub>) from the end of treatment.</p><p><strong>Results: </strong>Among the 7 patients enrolled, 2 discontinued treatment due to side effects and 1 was excluded after a cancer was diagnosed. Salovum alone or with SPC-Flakes did not improve the intestinal absorption in patients with SBS, while the administration of SPC-Flakes alone lead towards a trend of increased faecal volume. Weight, FFM, TBW, and ECW, as well as nutritional and inflammatory status, did not statistically change at the end of treatment (T<sub>3</sub>) as compared with T<sub>0</sub>. At T<sub>S</sub> water balance was restored.</p><p><strong>Conclusion: </strong>The administration of exogenous AF or the stimulation of endogenous AF seems to be unable to offer an effective therapy in patients with SBS. On the contrary, their administration appears to aggravate fluid loss and induce side effects.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819852061"},"PeriodicalIF":2.3000,"publicationDate":"2019-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819852061","citationCount":"0","resultStr":"{\"title\":\"Can the Antisecretory Factor Be Considered a New Therapy for the Short Bowel Syndrome?\",\"authors\":\"Maria Teresa Viggiani, Alfredo Di Leo, Michele Barone\",\"doi\":\"10.1177/1178638819852061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objective: </strong>The antisecretory factor (AF) exerts antisecretory and anti-inflammatory properties in the bowel. The aim of this study was to evaluate the effect of exogenous AF (Salovum) or cereals stimulating the endogenous AF (SPC-Flakes), given alone or in combination, in patients with short bowel syndrome (SBS).</p><p><strong>Methods: </strong>Patients received Salovum alone at T<sub>0</sub> -T<sub>1</sub>, Salovum plus SPC-Flakes at T<sub>1</sub> -T<sub>2</sub>, and SPC-Flakes alone at T<sub>2</sub> -T<sub>3</sub>. At T<sub>0</sub> and T<sub>3</sub>, water balance, weight, lean mass (FFM), total body water (TBW), extracellular water (ECW), and nutritional and inflammatory biochemical parameters were evaluated. The water balance was also measured at T<sub>1</sub>, T<sub>2</sub>, and 30 days (T<sub>S</sub>) from the end of treatment.</p><p><strong>Results: </strong>Among the 7 patients enrolled, 2 discontinued treatment due to side effects and 1 was excluded after a cancer was diagnosed. Salovum alone or with SPC-Flakes did not improve the intestinal absorption in patients with SBS, while the administration of SPC-Flakes alone lead towards a trend of increased faecal volume. Weight, FFM, TBW, and ECW, as well as nutritional and inflammatory status, did not statistically change at the end of treatment (T<sub>3</sub>) as compared with T<sub>0</sub>. At T<sub>S</sub> water balance was restored.</p><p><strong>Conclusion: </strong>The administration of exogenous AF or the stimulation of endogenous AF seems to be unable to offer an effective therapy in patients with SBS. On the contrary, their administration appears to aggravate fluid loss and induce side effects.</p>\",\"PeriodicalId\":19396,\"journal\":{\"name\":\"Nutrition and Metabolic Insights\",\"volume\":\"12 \",\"pages\":\"1178638819852061\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2019-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/1178638819852061\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition and Metabolic Insights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/1178638819852061\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Metabolic Insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1178638819852061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Can the Antisecretory Factor Be Considered a New Therapy for the Short Bowel Syndrome?
Background and objective: The antisecretory factor (AF) exerts antisecretory and anti-inflammatory properties in the bowel. The aim of this study was to evaluate the effect of exogenous AF (Salovum) or cereals stimulating the endogenous AF (SPC-Flakes), given alone or in combination, in patients with short bowel syndrome (SBS).
Methods: Patients received Salovum alone at T0 -T1, Salovum plus SPC-Flakes at T1 -T2, and SPC-Flakes alone at T2 -T3. At T0 and T3, water balance, weight, lean mass (FFM), total body water (TBW), extracellular water (ECW), and nutritional and inflammatory biochemical parameters were evaluated. The water balance was also measured at T1, T2, and 30 days (TS) from the end of treatment.
Results: Among the 7 patients enrolled, 2 discontinued treatment due to side effects and 1 was excluded after a cancer was diagnosed. Salovum alone or with SPC-Flakes did not improve the intestinal absorption in patients with SBS, while the administration of SPC-Flakes alone lead towards a trend of increased faecal volume. Weight, FFM, TBW, and ECW, as well as nutritional and inflammatory status, did not statistically change at the end of treatment (T3) as compared with T0. At TS water balance was restored.
Conclusion: The administration of exogenous AF or the stimulation of endogenous AF seems to be unable to offer an effective therapy in patients with SBS. On the contrary, their administration appears to aggravate fluid loss and induce side effects.
期刊介绍：
Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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