{"title":"三氯异氰尿酸对吡唑的无溶剂机械化学氯化反应","authors":"Chi-Min Chen, Jia-Xin Chen and Ching Tat To","doi":"10.1039/D3GC00170A","DOIUrl":null,"url":null,"abstract":"<p >A solvent-free, rapid and operationally simple method for the chlorination of pyrazoles with trichloroisocyanuric acid to access 4-chloropyrazole derivatives is described. This high-yielding protocol avoids tedious column chromatography and reduces solvent consumption. Mechanistic studies suggested an electrophilic aromatic substitution mechanism. This system also gives good green chemistry metrics.</p>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 7","pages":" 2559-2562"},"PeriodicalIF":9.3000,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solvent-free mechanochemical chlorination of pyrazoles with trichloroisocyanuric acid†\",\"authors\":\"Chi-Min Chen, Jia-Xin Chen and Ching Tat To\",\"doi\":\"10.1039/D3GC00170A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A solvent-free, rapid and operationally simple method for the chlorination of pyrazoles with trichloroisocyanuric acid to access 4-chloropyrazole derivatives is described. This high-yielding protocol avoids tedious column chromatography and reduces solvent consumption. Mechanistic studies suggested an electrophilic aromatic substitution mechanism. This system also gives good green chemistry metrics.</p>\",\"PeriodicalId\":78,\"journal\":{\"name\":\"Green Chemistry\",\"volume\":\" 7\",\"pages\":\" 2559-2562\"},\"PeriodicalIF\":9.3000,\"publicationDate\":\"2023-03-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2023/gc/d3gc00170a\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2023/gc/d3gc00170a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Solvent-free mechanochemical chlorination of pyrazoles with trichloroisocyanuric acid†
A solvent-free, rapid and operationally simple method for the chlorination of pyrazoles with trichloroisocyanuric acid to access 4-chloropyrazole derivatives is described. This high-yielding protocol avoids tedious column chromatography and reduces solvent consumption. Mechanistic studies suggested an electrophilic aromatic substitution mechanism. This system also gives good green chemistry metrics.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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